Jamieson, S., Barraclough, R., and Rudland, P.S. (1990) Production of the metastatic phenotype with DNA from metastatic cells but not with oncogenic DNA. Cell Biology International Reports, 14 (8). pp. 712-725. ISSN 1065-6995 (doi:10.1016/0309-1651(90)91190-F)
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Publisher's URL: http://dx.doi.org/10.1016/0309-1651(90)91190-F
Although the tumorigenic phenotype can be transferred by transfecting DNA from a variety of human tumours into 3T3 mouse fibroblasts, the ability to transfer the metastatic phenotype in a similar manner in syngeneic animals is largely unknown. We now report that transfection of a rat mammary epithelial cell line Rama 37, which produces nonmetastasizing adenomatous tumours in syngeneic rats, with DNA from a metastasizing rat mammary cell line, Rama 800, yields some transfectants with reproducible metastatic capabilities. Nonspecific DNA or the oncogenes EJ-ras-1, or Polyoma Large T Antigen fail in this respect, although their transfectants often possess increased tumorigenic potential.
|Glasgow Author(s):||Jamieson, Dr Susan|
|Authors:||Jamieson, S., Barraclough, R., and Rudland, P.S.|
|College/School:||College of Medical Veterinary and Life Sciences > School of Medicine > Clinical Specialities|
|Journal Name:||Cell Biology International Reports|
|Published Online:||11 December 2004|