Production of the metastatic phenotype with DNA from metastatic cells but not with oncogenic DNA

Jamieson, S. , Barraclough, R. and Rudland, P.S. (1990) Production of the metastatic phenotype with DNA from metastatic cells but not with oncogenic DNA. Cell Biology International Reports, 14(8), pp. 712-725. (doi:10.1016/0309-1651(90)91190-F)

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Publisher's URL: http://dx.doi.org/10.1016/0309-1651(90)91190-F

Abstract

Although the tumorigenic phenotype can be transferred by transfecting DNA from a variety of human tumours into 3T3 mouse fibroblasts, the ability to transfer the metastatic phenotype in a similar manner in syngeneic animals is largely unknown. We now report that transfection of a rat mammary epithelial cell line Rama 37, which produces nonmetastasizing adenomatous tumours in syngeneic rats, with DNA from a metastasizing rat mammary cell line, Rama 800, yields some transfectants with reproducible metastatic capabilities. Nonspecific DNA or the oncogenes EJ-ras-1, or Polyoma Large T Antigen fail in this respect, although their transfectants often possess increased tumorigenic potential.

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Jamieson, Professor Susan
Authors: Jamieson, S., Barraclough, R., and Rudland, P.S.
College/School:College of Medical Veterinary and Life Sciences > School of Medicine, Dentistry & Nursing > Clinical Specialities
Journal Name:Cell Biology International Reports
ISSN:1065-6995
ISSN (Online):2041-5346
Published Online:11 December 2004

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