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Production of the metastatic phenotype with DNA from metastatic cells but not with oncogenic DNA

Jamieson, S., Barraclough, R., and Rudland, P.S. (1990) Production of the metastatic phenotype with DNA from metastatic cells but not with oncogenic DNA. Cell Biology International Reports, 14 (8). pp. 712-725. ISSN 1065-6995 (doi:10.1016/0309-1651(90)91190-F)

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Publisher's URL: http://dx.doi.org/10.1016/0309-1651(90)91190-F

Abstract

Although the tumorigenic phenotype can be transferred by transfecting DNA from a variety of human tumours into 3T3 mouse fibroblasts, the ability to transfer the metastatic phenotype in a similar manner in syngeneic animals is largely unknown. We now report that transfection of a rat mammary epithelial cell line Rama 37, which produces nonmetastasizing adenomatous tumours in syngeneic rats, with DNA from a metastasizing rat mammary cell line, Rama 800, yields some transfectants with reproducible metastatic capabilities. Nonspecific DNA or the oncogenes EJ-ras-1, or Polyoma Large T Antigen fail in this respect, although their transfectants often possess increased tumorigenic potential.

Item Type:Article
Status:Published
Refereed:Yes
Glasgow Author(s):Jamieson, Dr Susan
Authors: Jamieson, S., Barraclough, R., and Rudland, P.S.
College/School:College of Medical Veterinary and Life Sciences > School of Medicine > Clinical Specialities
Journal Name:Cell Biology International Reports
ISSN:1065-6995
ISSN (Online):2041-5346
Published Online:11 December 2004

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