Jamieson, S. , Barraclough, R. and Rudland, P.S. (1990) Production of the metastatic phenotype with DNA from metastatic cells but not with oncogenic DNA. Cell Biology International Reports, 14(8), pp. 712-725. (doi: 10.1016/0309-1651(90)91190-F)
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Publisher's URL: http://dx.doi.org/10.1016/0309-1651(90)91190-F
Abstract
Although the tumorigenic phenotype can be transferred by transfecting DNA from a variety of human tumours into 3T3 mouse fibroblasts, the ability to transfer the metastatic phenotype in a similar manner in syngeneic animals is largely unknown. We now report that transfection of a rat mammary epithelial cell line Rama 37, which produces nonmetastasizing adenomatous tumours in syngeneic rats, with DNA from a metastasizing rat mammary cell line, Rama 800, yields some transfectants with reproducible metastatic capabilities. Nonspecific DNA or the oncogenes <sub>EJ-ras-1,</sub> or Polyoma Large T Antigen fail in this respect, although their transfectants often possess increased tumorigenic potential.
| Item Type: | Articles |
|---|---|
| Status: | Published |
| Refereed: | Yes |
| Glasgow Author(s) Enlighten ID: | Jamieson, Professor Susan |
| Authors: | Jamieson, S., Barraclough, R., and Rudland, P.S. |
| College/School: | College of Medical Veterinary and Life Sciences > School of Medicine, Dentistry & Nursing > Clinical Specialities |
| Journal Name: | Cell Biology International Reports |
| ISSN: | 1065-6995 |
| ISSN (Online): | 2041-5346 |
| Published Online: | 11 December 2004 |
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