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Energy balance during acute respiratory exacerbations in children with cystic fibrosis

Reilly, J.J., Ralston, J.M., Paton, J.Y., Edwards, C.A., Weaver, L.T., Wilkinson, J., and Evans, T.J. (1999) Energy balance during acute respiratory exacerbations in children with cystic fibrosis. European Respiratory Journal, 13 (4). pp. 804-809. ISSN 0903-1936 (doi:10.1034/j.1399-3003.1999.13d18.x)

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Publisher's URL: http://dx.doi.org/10.1034/j.1399-3003.1999.13d18.x

Abstract

Acute respiratory exacerbations have been proposed to contribute to the negative energy balance which causes undernutrition in cystic fibrosis. However, no studies have measured their effect on all components of energy balance. The aim of this study was to measure the effect of an acute respiratory exacerbation on energy balance. Fourteen children (six females, eight males, mean+/-SD age 9.9+/-2.4 yrs) were studied when well and during the course of an acute respiratory exacerbation treated with intravenous antimicrobial therapy. The total energy expenditure was measured using the doubly-labelled water method, resting energy expenditure by ventilated hood indirect calorimetry, energy intake by household measures records, and fat malabsorption from measurements of dietary fat intake and faecal fat output. The exacerbation was associated with a significant reduction in energy intake (mean paired difference 47 kJ x kg of body weight(-1) x day(-1), p<0.01). Changes in fat malabsorption and resting energy expenditure were negligible. The absence of significant changes in body weight and composition, together with the trend towards lower total energy expenditure, suggested no marked negative energy balance during the exacerbation. In conclusion, treatment of acute respiratory exacerbation with intravenous antimicrobial therapy represents a relatively minor challenge to energy balance and nutritional status in children with cystic fibrosis.

Item Type:Article
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Evans, Prof Tom and Weaver, Prof Lawrence and Edwards, Prof Christine and Paton, Dr James and Wilkinson, Dr Jane
Authors: Reilly, J.J., Ralston, J.M., Paton, J.Y., Edwards, C.A., Weaver, L.T., Wilkinson, J., and Evans, T.J.
College/School:College of Medical Veterinary and Life Sciences > Institute of Infection Immunity and Inflammation > Bacteriology
College of Medical Veterinary and Life Sciences > School of Medicine
College of Medical Veterinary and Life Sciences > School of Medicine > Clinical Specialities
Journal Name:European Respiratory Journal
Journal Abbr.:Eur Respir J.
ISSN:0903-1936
ISSN (Online):1399-3003
Published Online:25 December 2001
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