Association between preterm delivery and subsequent C-reactive protein: a retrospective cohort study

Hastie, C.E. , Smith, G.C.S., Mackay, D. and Pell, J.P. (2011) Association between preterm delivery and subsequent C-reactive protein: a retrospective cohort study. American Journal of Obstetrics and Gynecology, 205(6), 556.e1-556.e4. (doi: 10.1016/j.ajog.2011.06.080)

Abstract

<p><b>Objective:</b> We sought to determine whether giving birth preterm is associated with raised maternal C-reactive protein (CRP) in later life and whether the association is specific to indicated or spontaneous delivery.</p> <p><b>Study Design:</b> This was a Scotland-wide retrospective cohort study of 1124 women who had a first pregnancy resulting in a singleton, liveborn infant delivered between 24-43 weeks' gestation. Linear regression analysis was used to examine the association between preterm delivery and subsequent CRP concentration.</p> <p><b>Results:</b> The difference in CRP between women who delivered term and preterm was nonsignificant on univariate analysis (beta coefficient 0.04, P = .18) but was statistically significant following adjustment for potential confounders (beta coefficient 0.05, P < .05). On subgroup analysis the association was specific to women who had had indicated preterm delivery (unadjusted beta coefficient 0.09, P < .01; adjusted beta coefficient 0.09, P < .01). </p> <p><b>Conclusion:</b> Women who undergo indicated preterm delivery are at increased risk of raised CRP in later life.</p>

• Item Type: Articles
• Status: Published
• Refereed: Yes
• Glasgow Author(s) Enlighten ID: Hastie, Dr Claire and Mackay, Professor Daniel and Pell, Professor Jill
• Authors: Hastie, C.E., Smith, G.C.S., Mackay, D., and Pell, J.P.
• College/School: College of Medical Veterinary and Life Sciences > School of Health & Wellbeing > Public Health; College of Medical Veterinary and Life Sciences > School of Cardiovascular & Metabolic Health
• Journal Name: American Journal of Obstetrics and Gynecology
• ISSN: 0002-9378
• ISSN (Online): 1097-6868
• Published Online: 29 June 2011