The role of miRNA in stem cell pluripotency and commitment to the vascular endothelial lineage

White, K., Kane, N. M., Milligan, G. and Baker, A. H. (2012) The role of miRNA in stem cell pluripotency and commitment to the vascular endothelial lineage. Microcirculation, 19(3), pp. 196-207. (doi: 10.1111/j.1549-8719.2012.00161.x)

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Publisher's URL: http://dx.doi.org/10.1111/j.1549-8719.2012.00161.x

Abstract

Vascular endothelial cells derived from human pluripotent stem cells have substantial potential for the development of novel vascular therapeutics and cell based therapies for the repair of ischemic damage. To gain maximum benefit from this source of cells a complete understanding of the changes in gene expression and how they are regulated is required. microRNAs have been demonstrated to play a critical roles in controlling stem cell pluripotency and differentiation and are important for mature endothelial cell function. Specific microRNAs which determine stem cell fate have been identified for a number of different cell lineages, however in the case of differentiation and specification of vascular endothelial cells this is yet to be fully elucidated.

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Baker, Professor Andrew and White, Miss Katie and Kane, Dr Nicole and Milligan, Professor Graeme
Authors: White, K., Kane, N. M., Milligan, G., and Baker, A. H.
College/School:College of Medical Veterinary and Life Sciences > Institute of Cardiovascular and Medical Sciences
College of Medical Veterinary and Life Sciences > School of Psychology & Neuroscience
Journal Name:Microcirculation
Publisher:John Wiley & Sons Ltd.
ISSN:1073-9688
ISSN (Online):1549-8719
Published Online:27 March 2012

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Project CodeAward NoProject NamePrincipal InvestigatorFunder's NameFunder RefLead Dept
478611Interrogation and manipulation of micro RNA during differentiation of human ES cells to cardiomyocyte and vascular lineagesAndrew BakerBritish Heart Foundation (BHF)PG/08/107/26160RI CARDIOVASCULAR & MEDICAL SCIENCES