White, K., Kane, N. M., Milligan, G. and Baker, A. H. (2012) The role of miRNA in stem cell pluripotency and commitment to the vascular endothelial lineage. Microcirculation, 19(3), pp. 196-207. (doi: 10.1111/j.1549-8719.2012.00161.x)
Full text not currently available from Enlighten.
Publisher's URL: http://dx.doi.org/10.1111/j.1549-8719.2012.00161.x
Abstract
Vascular endothelial cells derived from human pluripotent stem cells have substantial potential for the development of novel vascular therapeutics and cell based therapies for the repair of ischemic damage. To gain maximum benefit from this source of cells a complete understanding of the changes in gene expression and how they are regulated is required. microRNAs have been demonstrated to play a critical roles in controlling stem cell pluripotency and differentiation and are important for mature endothelial cell function. Specific microRNAs which determine stem cell fate have been identified for a number of different cell lineages, however in the case of differentiation and specification of vascular endothelial cells this is yet to be fully elucidated.
Item Type: | Articles |
---|---|
Status: | Published |
Refereed: | Yes |
Glasgow Author(s) Enlighten ID: | Baker, Professor Andrew and White, Miss Katie and Kane, Dr Nicole and Milligan, Professor Graeme |
Authors: | White, K., Kane, N. M., Milligan, G., and Baker, A. H. |
College/School: | College of Medical Veterinary and Life Sciences > School of Cardiovascular & Metabolic Health College of Medical Veterinary and Life Sciences > School of Psychology & Neuroscience |
Journal Name: | Microcirculation |
Publisher: | John Wiley & Sons Ltd. |
ISSN: | 1073-9688 |
ISSN (Online): | 1549-8719 |
Published Online: | 27 March 2012 |
University Staff: Request a correction | Enlighten Editors: Update this record