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Preparation and reactions of desymmetrised cobalt alkyne complexes

Carbery, D.R., Kerr, W.J., Lindsay, D., Scott, J.S., and Watson, S.P. (2000) Preparation and reactions of desymmetrised cobalt alkyne complexes. Tetrahedron Letters, 41 (17). pp. 3235-3239. ISSN 0040-4039 (doi:10.1016/S0040-4039(00)00356-7)

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Publisher's URL: http://dx.doi.org/10.1016/S0040-4039(00)00356-7

Abstract

Prochiral alkyne hexacarbonyl dicobalt complexes are desymmetrised directly with brucine N-oxide in the presence of a phosphine or phosphite ligand to produce the corresponding phosphorus-containing pentacarbonyl complex with appreciable enantiomeric excess. In Pauson–Khand reactions, it is found that the enantiomeric integrity of the desymmetrised complex is conserved in the cyclopentenone product. Moreover, the major enantiomer obtained in these reactions is opposite to that from a direct brucine N-oxide promoted Pauson–Khand reaction, allowing the preparation of either enantiomeric cyclopentenone in enriched form from a single source of chirality.

Item Type:Article
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Lindsay, Dr David and Carbery, Dr David and Kerr, Prof William
Authors: Carbery, D.R., Kerr, W.J., Lindsay, D., Scott, J.S., and Watson, S.P.
College/School:College of Science and Engineering > School of Chemistry
Journal Name:Tetrahedron Letters
ISSN:0040-4039
Published Online:2000

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