Smith, K., Martin, L., Rinaldi, A., Rajendran, R., Ramage, G. and Walker, D. (2012) Activity of Pyocin S2 against Pseudomonas aeruginosa biofilms. Antimicrobial Agents and Chemotherapy, 56(3), pp. 1599-1601. (doi: 10.1128/AAC.05714-11)
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Abstract
In cystic fibrosis patients, chronic lung infection with <i>Pseudomonas aeruginosa</i> and the associated decline in lung function is the major cause of mortality. In this report we show that pyocin S2 displays potent activity against <i>P. aeruginosa</i> biofilms, thus representing a potentially improved therapeutic option. Using an invertebrate model of <i>P. aeruginosa</i> infection we also show that pyocin S2 is highly active <i>in vivo</i>.
| Item Type: | Articles |
|---|---|
| Status: | Published |
| Refereed: | Yes |
| Glasgow Author(s) Enlighten ID: | Smith, Dr Karen and Rajendran, Dr Ranjith and Rinaldi, Mrs Angela and Walker, Professor Daniel |
| Authors: | Smith, K., Martin, L., Rinaldi, A., Rajendran, R., Ramage, G., and Walker, D. |
| College/School: | College of Medical Veterinary and Life Sciences > School of Infection & Immunity |
| Journal Name: | Antimicrobial Agents and Chemotherapy |
| ISSN: | 0066-4804 |
| ISSN (Online): | 1098-6596 |
| Published Online: | 19 December 2011 |
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