Activity of Pyocin S2 against Pseudomonas aeruginosa biofilms

Smith, K., Martin, L., Rinaldi, A., Rajendran, R., Ramage, G. and Walker, D. (2012) Activity of Pyocin S2 against Pseudomonas aeruginosa biofilms. Antimicrobial Agents and Chemotherapy, 56(3), pp. 1599-1601. (doi:10.1128/AAC.05714-11)

Smith, K., Martin, L., Rinaldi, A., Rajendran, R., Ramage, G. and Walker, D. (2012) Activity of Pyocin S2 against Pseudomonas aeruginosa biofilms. Antimicrobial Agents and Chemotherapy, 56(3), pp. 1599-1601. (doi:10.1128/AAC.05714-11)

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Abstract

In cystic fibrosis patients, chronic lung infection with <i>Pseudomonas aeruginosa</i> and the associated decline in lung function is the major cause of mortality. In this report we show that pyocin S2 displays potent activity against <i>P. aeruginosa</i> biofilms, thus representing a potentially improved therapeutic option. Using an invertebrate model of <i>P. aeruginosa</i> infection we also show that pyocin S2 is highly active <i>in vivo</i>.

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Smith, Dr Karen and Rajendran, Dr Ranjith and Rinaldi, Mrs Angela and Walker, Professor Daniel
Authors: Smith, K., Martin, L., Rinaldi, A., Rajendran, R., Ramage, G., and Walker, D.
College/School:College of Medical Veterinary and Life Sciences > Institute of Infection Immunity and Inflammation
Journal Name:Antimicrobial Agents and Chemotherapy
ISSN:0066-4804
ISSN (Online):1098-6596
Published Online:19 December 2011

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