Mason, A., Malik, S., Russell, R.K., Bishop, J., McGrogan, P. and Ahmed, S.F. (2011) Impact of inflammatory bowel disease on pubertal growth. Hormone Research in Paediatrics, 76(5), pp. 293-299. (doi: 10.1159/000329991)
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Publisher's URL: http://dx.doi.org/10.1159/000329991
Abstract
<p><b>Background:</b> Puberty is thought to be commonly affected in adolescents with inflammatory bowel disease (IBD).</p> <p><b>Aims:</b> To determine the impact of Crohn’s disease (CD) and ulcerative colitis (UC) on the pubertal growth spurt.</p> <p><b>Methods:</b> Retrospective study of 30 boys with CD (CD-M), 11 girls with CD (CD-F), 14 boys with UC (UC-M) and 12 girls with UC (UC-F). Pubertal growth was assessed by calculating peak height velocity SDS (PHV SDS), height SDS at diagnosis (Ht<sub>Diag</sub>) and height SDS at PHV (Ht<sub>PHV</sub>) and age at PHV (Age<sub>PHV</sub>). Systemic markers of disease activity were also collected.</p> <p><b>Results:</b> Altered parameters of pubertal growth were observed in the CD groups compared to the normal population: in the CD-M group, median Ht<sub>Diag</sub> was –0.56 (p = 0.001) and median Age<sub>PHV</sub> was 14.45 years (p = 0.004), and in the CD-F group, median Ht<sub>Diag</sub> was –1.14 (p = 0.007) and Ht<sub>PHV</sub> was –0.79 (p = 0.039). Individually, 8/30 CD-M cases had one or more parameter affected: 2 boys had Ht<sub>Diag</sub> <–2, 3 boys had Ht<sub>PHV</sub> <–2, 2 boys had an Age<sub>PHV</sub> >2 years above population mean, and 2 boys had a PHV SDS <–2. In the whole group, Age<sub>PHV</sub> showed an association with erythrocyte sedimentation rate (r = 0.4; p = 0.005) and an inverse association with BMI (r = 0.4; p = 0.001).</p> <p><b>Conclusion:</b> Disorders of pubertal growth are more likely to occur in CD and, particularly, in boys.</p>
Item Type: | Articles |
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Status: | Published |
Refereed: | Yes |
Glasgow Author(s) Enlighten ID: | Russell, Dr Richard and McGrogan, Dr Paraic and Ahmed, Professor Syed Faisal |
Authors: | Mason, A., Malik, S., Russell, R.K., Bishop, J., McGrogan, P., and Ahmed, S.F. |
College/School: | College of Medical Veterinary and Life Sciences > School of Medicine, Dentistry & Nursing |
Journal Name: | Hormone Research in Paediatrics |
ISSN: | 1663-2818 |
ISSN (Online): | 1663-2826 |
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