Myant, K. and Sansom, O.J. (2011) Wnt/Myc interactions in intestinal cancer: partners in crime. Experimental Cell Research, 317(19), pp. 2725-2731. (doi: 10.1016/j.yexcr.2011.08.001)
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Abstract
Loss of the APC (adenomatous polyposis coli) gene in colorectal cancer leads to a rapid deregulation of TCF/LEF target genes. Of all these target genes, the transcription factor c-MYC appears the most critical. In this review we will discuss the interplay of Wnt and c-MYC signaling during intestinal homeostasis and transformation. Furthermore, we will discuss recent data showing that further deregulation of c-MYC levels during colorectal carcinogenesis may drive tumor progression. Moreover, understanding these additional control mechanisms may allow targeting of c-MYC during colorectal carcinogenesis.
| Item Type: | Articles |
|---|---|
| Status: | Published |
| Refereed: | Yes |
| Glasgow Author(s) Enlighten ID: | Myant, Dr Kevin and Sansom, Professor Owen |
| Authors: | Myant, K., and Sansom, O.J. |
| College/School: | College of Medical Veterinary and Life Sciences > School of Cancer Sciences |
| Journal Name: | Experimental Cell Research |
| ISSN: | 0014-4827 |
| Published Online: | 07 August 2011 |
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