Wnt/Myc interactions in intestinal cancer: partners in crime

Myant, K. and Sansom, O.J. (2011) Wnt/Myc interactions in intestinal cancer: partners in crime. Experimental Cell Research, 317(19), pp. 2725-2731. (doi:10.1016/j.yexcr.2011.08.001)

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Abstract

Loss of the APC (adenomatous polyposis coli) gene in colorectal cancer leads to a rapid deregulation of TCF/LEF target genes. Of all these target genes, the transcription factor c-MYC appears the most critical. In this review we will discuss the interplay of Wnt and c-MYC signaling during intestinal homeostasis and transformation. Furthermore, we will discuss recent data showing that further deregulation of c-MYC levels during colorectal carcinogenesis may drive tumor progression. Moreover, understanding these additional control mechanisms may allow targeting of c-MYC during colorectal carcinogenesis.

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Myant, Dr Kevin and Sansom, Professor Owen
Authors: Myant, K., and Sansom, O.J.
College/School:College of Medical Veterinary and Life Sciences > Institute of Cancer Sciences
Journal Name:Experimental Cell Research
ISSN:0014-4827
Published Online:07 August 2011

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