Metabolomic profiling of Drosophila using liquid chromatography Fourier transform mass spectrometry

Kamleh, M.A., Hobani, Y., Dow, J.A.T. and Watson, D.G. (2008) Metabolomic profiling of Drosophila using liquid chromatography Fourier transform mass spectrometry. FEBS Letters, 582(19), pp. 2916-2922. (doi:10.1016/j.febslet.2008.07.029)

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Publisher's URL: http://dx.doi.org/10.1016/j.febslet.2008.07.029

Abstract

Hydrophilic interaction chromatography (HILIC) interfaced with an Orbitrap Fourier transform mass spectrometer (FT-MS) was used to carry out metabolomic profiling of the classical Drosophila mutation, rosy (ry). This gene encodes a xanthine oxidase/dehydrogenase. In addition to validating the technology by detecting the same changes in xanthine, hypoxanthine, urate and allantoin that have been reported classically, completely unsuspected changes were detected in each of the tryptophan, arginine, pyrimidine and glycerophospholipid metabolism pathways. The rosy mutation thus ramifies far more widely than previously detected.

Item Type:Articles
Keywords:Metabolomics, Fourier transform mass spectrometry, <i>Drosophila</i>
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Dow, Professor Julian
Authors: Kamleh, M.A., Hobani, Y., Dow, J.A.T., and Watson, D.G.
Subjects:Q Science > QH Natural history > QH426 Genetics
College/School:College of Medical Veterinary and Life Sciences > Institute of Molecular Cell and Systems Biology
Journal Name:FEBS Letters
ISSN:0014-5793

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