Simulation of haemodynamic flow in head and neck cancer chemotherapy

Rhode, S., Paul, M.C. , Martens, E. and Campbell, D.F. (2011) Simulation of haemodynamic flow in head and neck cancer chemotherapy. BioMedical Engineering OnLine, 10(1), p. 104. (doi:10.1186/1475-925X-10-104)

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Publisher's URL: http://dx.doi.org/10.1186/1475-925X-10-104

Abstract

Background: In recent years, intra arterial chemotherapy has become an important component in head and neck cancer treatment. However, therapy success can vary significantly and consistent treatment guidelines are missing. The purpose of this study was to create a computer simulation of the chemical agent injection in the head and neck arteries to investigate the distribution and concentration of the chemical. Methods: Realistic three dimensional patient specific geometry was created from image scan data. Pulsatile blood flow, turbulence, the chemical agent injection via a catheter, and the mixture between blood and the chemical were then simulated through the arterial network by computational fluid dynamics software. Results: The results show a consistent chemical distribution throughout all the arteries and this is ineffective. In addition, due to high wall shear stress and turbulence at the inner bifurcation wall, serious complications during the treatment could occur, for instance haemolysis or thrombosis. Conclusions: The modelled catheter position is insufficient to provide a high chemical agent concentration in the desired tumour feeding artery, which is vital for therapy success.

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Paul, Dr Manosh
Authors: Rhode, S., Paul, M.C., Martens, E., and Campbell, D.F.
College/School:College of Science and Engineering > School of Engineering > Systems Power and Energy
Journal Name:BioMedical Engineering OnLine
ISSN:1475-925X
Copyright Holders:Copyright © 2011 BioMed Central
First Published:First published in BioMedical Engineering OnLine 10(1):104
Publisher Policy:Reproduced in accordance with the copyright policy of the publisher

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