Acute motor neuropathy with antibodies to GM1 ganglioside

Gregson, N.A., Jones, D., Thomas, P.K. and Willison, H.J. (1991) Acute motor neuropathy with antibodies to GM1 ganglioside. Journal of Neurology, 238(8), pp. 447-451.

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We describe a 52-year-old man who had an acute-onset purely motor neuropathy fulfilling the diagnostic criteria for the Guillain-Barré syndrome, in whom virtually complete spontaneous recovery occurred by 1 year, and in whom high titres of polyclonal serum antibody to GM1, GD1b, asialo-GM1 and lacto-N-tetraose were detected. The titre of IgM antibody to GM1 fell during the course of the disease with a concomitant rise in the IgG titre. This case adds to the widening spectrum of disease associated with anti-GM1 antibodies and provides further evidence for a relationship between anti-GM1 antibodies and motor system disease.

Item Type:Articles
Glasgow Author(s) Enlighten ID:Willison, Professor Hugh
Authors: Gregson, N.A., Jones, D., Thomas, P.K., and Willison, H.J.
College/School:College of Medical Veterinary and Life Sciences > Institute of Infection Immunity and Inflammation
Journal Name:Journal of Neurology

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