Enlighten
Research publications by members of the University of Glasgow
home > services > Enlighten

Acute motor neuropathy with antibodies to GM1 ganglioside

Gregson, N.A., Jones, D., Thomas, P.K., and Willison, H.J. (1991) Acute motor neuropathy with antibodies to GM1 ganglioside. Journal of Neurology, 238 (8). pp. 447-451. ISSN 0340-5354

Full text not currently available from Enlighten.

Abstract

We describe a 52-year-old man who had an acute-onset purely motor neuropathy fulfilling the diagnostic criteria for the Guillain-Barré syndrome, in whom virtually complete spontaneous recovery occurred by 1 year, and in whom high titres of polyclonal serum antibody to GM1, GD1b, asialo-GM1 and lacto-N-tetraose were detected. The titre of IgM antibody to GM1 fell during the course of the disease with a concomitant rise in the IgG titre. This case adds to the widening spectrum of disease associated with anti-GM1 antibodies and provides further evidence for a relationship between anti-GM1 antibodies and motor system disease.

Item Type:Article
Status:Published
Refereed:Yes
Glasgow Author(s):Willison, Prof Hugh
Authors: Gregson, N.A., Jones, D., Thomas, P.K., and Willison, H.J.
College/School:College of Medical Veterinary and Life Sciences > Institute of Infection Immunity and Inflammation
Journal Name:Journal of Neurology
ISSN:0340-5354

University Staff: Request a correction | Enlighten Editors: Update this record