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Serum factor in Miller-Fisher variant of Guillain-Barré syndrome and neurotransmitter release

Roberts, M., Vincent, A., Newsom-Davis, J., and Willison, H.J. (1994) Serum factor in Miller-Fisher variant of Guillain-Barré syndrome and neurotransmitter release. Lancet, 343 (8895). pp. 454-5. ISSN 0140-6736 (doi:10.1016/S0140-6736(94)92694-8)

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Publisher's URL: http://dx.doi.org/10.1016/S0140-6736(94)92694-8

Abstract

Serum IgG autoantibodies to GQ1b ganglioside are associated with the acute phase of the Miller-Fisher syndrome (MFS). We investigated the effects of three anti-GQ1b-positive MFS sera in the mouse phrenic-nerve/diaphragm preparation. Miniature endplate potential frequencies increased eight-fold within 25 min, declined rapidly, and ceased altogether after 3 h, when nerve stimulation no longer evoked a response. One MFS convalescent serum (anti-GQ1b negative) and sera from healthy controls and from patients with other neurological diseases were without effect. Thus muscle weakness in MFS may be caused by a serum factor, likely to be GQ1b antibody, that leads to failure of acetylcholine release from motor nerve terminals.

Item Type:Article
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Willison, Prof Hugh
Authors: Roberts, M., Vincent, A., Newsom-Davis, J., and Willison, H.J.
College/School:College of Medical Veterinary and Life Sciences > Institute of Infection Immunity and Inflammation > Immunology
Journal Name:Lancet
Publisher:The Lancet Publishing Group
ISSN:0140-6736
ISSN (Online):1474-547X

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