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Immunoglobulin subclass distribution and binding characteristics of anti-GQ1b antibodies in Miller Fisher syndrome

Willison, H.J., and Veitch, J. (1994) Immunoglobulin subclass distribution and binding characteristics of anti-GQ1b antibodies in Miller Fisher syndrome. Journal of Neuroimmunology, 50 (2). pp. 159-165. ISSN 0165-5728 (doi:10.1016/0165-5728(94)90042-6)

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Publisher's URL: http://dx.doi.org/10.1016/0165-5728(94)90042-6

Abstract

Circulating IgG antibodies to carbohydrate determinants on GQ1b ganglioside are found in the acute phase sera of patients with Miller Fisher syndrome, a variant of Guillain-Barré syndrome. Here we report that the IgG subclass distribution of the anti-GQ1b antibodies is mainly restricted to IgG1 and IgG3 antibodies, subclasses typically associated with a T cell-dependent immune response to protein antigens. This is highly unusual in that IgG responses to carbohydrate determinants are typically of the IgG2 subclass. Anti-GQ1b antibodies also have a limited ability to bind GQ1b in a membrane-like environment, particularly at body temperature. These data suggest that the antigen initiating the immune response in MFS is not likely GQ1b but an unidentified cross-reactive glycoprotein antigen(s). Similar results were obtained for anti-GM1 IgG antibodies in Guillain-Barré syndrome.

Item Type:Article
Status:Published
Refereed:Yes
Glasgow Author(s):Willison, Prof Hugh
Authors: Willison, H.J., and Veitch, J.
College/School:College of Medical Veterinary and Life Sciences > Institute of Infection Immunity and Inflammation > Immunology
Journal Name:Journal of Neuroimmunology
ISSN:0165-5728
ISSN (Online):1872-8421

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