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Acute ataxic neuropathy with cross-reactive antibodies to GD1b and GD3 gangliosides

Willison, H.J., Almemar, A., Veitch, J., and Thrush, D. (1994) Acute ataxic neuropathy with cross-reactive antibodies to GD1b and GD3 gangliosides. Neurology, 44 (12). pp. 2395-2397. ISSN 0028-3878

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Abstract

We report a patient with an acute, self-limiting neuropathy consisting of ataxia and areflexia, but without ophthalmoplegia or limb weakness, with transient, high-titer serum IgG antibodies to a single NeuAc(alpha 2-8)NeuAc-linked disialosyl epitope, as found on GD1b and GD3 gangliosides. The serum did not react with GQ1b, GT1a, or GT1b. This atypical case, which most closely represents an incomplete Miller Fisher syndrome, indicates that anti-GD1b/GD3 antibodies may be able to induce sensory ataxia.

Item Type:Article
Status:Published
Refereed:Yes
Glasgow Author(s):Willison, Prof Hugh
Authors: Willison, H.J., Almemar, A., Veitch, J., and Thrush, D.
College/School:College of Medical Veterinary and Life Sciences > Institute of Infection Immunity and Inflammation > Immunology
Journal Name:Neurology
ISSN:0028-3878
ISSN (Online):1526-632X

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