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Autoimmune responses in peripheral nerve

Hartung, H.-P., Willison, H.J., Jung, S., Pette, M., Toyka, K.V., and Giegerich, G. (1996) Autoimmune responses in peripheral nerve. Springer Seminars in Immunopathology, 18 (1). pp. 97-123. ISSN 0344-4325 (doi:10.1007/BF00792612)

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Publisher's URL: http://dx.doi.org/10.1007/BF00792612

Abstract

The PNS is an immunocompetent organ. The participating cellular and humoral elements in the local immune circuitry have been identified. A number of acute and chronic neuropathies appear to result from disturbed immune homeostasis. The model disorder EAN has been useful in examining the induction, amplification and effector phase of autoimmune responses to peripheral nerve antigens. Potential autoantigens contained in the myelin sheath and on the axolemma have been characterized. Thus, the recent years have seen a rapid growth of information concerning the pathogenesis of the important group of immune-mediated neuropathies. It can be anticipated that the better understanding of the principal mechanisms of autoimmunity in the PNS will aid in the development of more specific and efficacious treatments for these crippling diseases.

Item Type:Article
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Willison, Prof Hugh
Authors: Hartung, H.-P., Willison, H.J., Jung, S., Pette, M., Toyka, K.V., and Giegerich, G.
College/School:College of Medical Veterinary and Life Sciences > Institute of Infection Immunity and Inflammation > Immunology
Journal Name:Springer Seminars in Immunopathology
ISSN:0344-4325
ISSN (Online):1432-2196

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