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Mechanisms of action of anti-GM1 and anti-GQ1b ganglioside antibodies in Guillain-Barré syndrome

Willison, H.J., O'Hanlon, G.M., Paterson, G., O'Leary, C.P., Veitch, J., Wilson, G., Roberts, M., Tang, T., and Vincent, A. (1997) Mechanisms of action of anti-GM1 and anti-GQ1b ganglioside antibodies in Guillain-Barré syndrome. Journal of Infectious Diseases, 176 (s2). s144-s149. ISSN 0022-1899 (doi:10.1086/513799)

Full text not currently available from Enlighten.

Publisher's URL: http://dx.doi.org/10.1086/513799

Abstract

Anti-GM1 and anti-GQ1b ganglioside antibodies are found in association with acute and chronic peripheral neuropathies, including Guillain-Barré syndrome. They are believed to arise as a result of molecular mimicry with immunogenic microbial polysaccharides. Although anti-ganglioside antibodies are suspected to play a causal role in neuropathy pathogenesis, the details of this have yet to be proven. The approach in this laboratory to solving this issue has been to generate anti-GM1 and anti-GQ1b monoclonal antibodies from peripheral blood lymphocytes of affected patients and to study their immunolocalization in peripheral nerve and their electrophysiologic effects in animal models in which peripheral nerve sites are exposed to anti-ganglioside antibodies. These data show that anti-ganglioside antibody-reactive epitopes are widely distributed in peripheral nerve and can cause electrophysiologic abnormalities in a variety of model systems; thus, these data support the view that anti-ganglioside antibody-reactive epitopes may directly contribute to neuropathy pathogenesis.

Item Type:Article
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Willison, Prof Hugh and O'Leary, Dr Colin
Authors: Willison, H.J., O'Hanlon, G.M., Paterson, G., O'Leary, C.P., Veitch, J., Wilson, G., Roberts, M., Tang, T., and Vincent, A.
College/School:College of Medical Veterinary and Life Sciences > Institute of Infection Immunity and Inflammation > Immunology
College of Medical Veterinary and Life Sciences > School of Medicine
Journal Name:Journal of Infectious Diseases
Journal Abbr.:J Infect Dis.
ISSN:0022-1899
ISSN (Online):1537-6613

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