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Immune-mediated peripheral neuropathies and voltage-gated sodiums channels

Benatar, M., Willison, H.J., and Vincent, A. (1999) Immune-mediated peripheral neuropathies and voltage-gated sodiums channels. Muscle and Nerve, 22 (1). pp. 108-110. ISSN 0148-639X (doi:10.1002/(SICI)1097-4598(199901)22:1<108::AID-MUS16>3.0.CO;2-I)

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Publisher's URL: http://dx.doi.org/10.1002/(SICI)1097-4598(199901)22:1<108::AID-MUS16>3.0.CO;2-I

Abstract

Antibodies to GM1 ganglioside are found in some patients with the Guillain-Barré syndrome and multifocal motor neuropathy, and may alter neuronal excitability. We measured voltage-gated sodium channel (VGSC) function by 22Na+ influx in a motor neuronal cell line (NSC19) in which we demonstrated GM1 ganglioside and tetrodotoxin-sensitive VGSC function. We were unable to detect any effect of peripheral neuropathy plasmas, with or without complement, on VGSC function in NSC19 cells.

Item Type:Article
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Willison, Prof Hugh
Authors: Benatar, M., Willison, H.J., and Vincent, A.
College/School:College of Medical Veterinary and Life Sciences > Institute of Infection Immunity and Inflammation > Immunology
Journal Name:Muscle and Nerve
ISSN:0148-639X
ISSN (Online):1097-4598

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