Immune-mediated peripheral neuropathies and voltage-gated sodiums channels

Benatar, M., Willison, H.J. and Vincent, A. (1999) Immune-mediated peripheral neuropathies and voltage-gated sodiums channels. Muscle and Nerve, 22(1), pp. 108-110. (doi: 10.1002/(SICI)1097-4598(199901)22:1<108::AID-MUS16>3.0.CO;2-I)

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Antibodies to GM<sub>1</sub> ganglioside are found in some patients with the Guillain-Barré syndrome and multifocal motor neuropathy, and may alter neuronal excitability. We measured voltage-gated sodium channel (VGSC) function by <sup>22</sup>Na<sup>+</sup> influx in a motor neuronal cell line (NSC19) in which we demonstrated GM<sub>1</sub> ganglioside and tetrodotoxin-sensitive VGSC function. We were unable to detect any effect of peripheral neuropathy plasmas, with or without complement, on VGSC function in NSC19 cells.

Item Type:Articles
Glasgow Author(s) Enlighten ID:Willison, Professor Hugh
Authors: Benatar, M., Willison, H.J., and Vincent, A.
College/School:College of Medical Veterinary and Life Sciences > School of Infection & Immunity
Journal Name:Muscle and Nerve
ISSN (Online):1097-4598

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