Immune-mediated peripheral neuropathies and voltage-gated sodiums channels

Abstract

Antibodies to GM₁ ganglioside are found in some patients with the Guillain-Barré syndrome and multifocal motor neuropathy, and may alter neuronal excitability. We measured voltage-gated sodium channel (VGSC) function by ²²Na⁺ influx in a motor neuronal cell line (NSC19) in which we demonstrated GM₁ ganglioside and tetrodotoxin-sensitive VGSC function. We were unable to detect any effect of peripheral neuropathy plasmas, with or without complement, on VGSC function in NSC19 cells.