Prendergast, M.M., Willison, H.J. and Moran, A.P. (1999) Human monoclonal immunoglobulin M antibodies to ganglioside GM1 show diverse cross-reactivities with lipopolysaccharides of Campylobacter jejuni strains associated with Guillain-Barré syndrome. Infection and Immunity, 67(7), pp. 3698-3701.
Full text not currently available from Enlighten.
Abstract
We examined the reactivity of a panel of anti-GM<sub>1</sub> immunoglobulin M monoclonal antibodies (MAbs) cloned from multifocal motor neuropathy patients with lipopolysaccharides (LPSs) of <i>Campylobacter jejuni</i> strains, including serotype O:41 strains associated with Guillain-Barré syndrome. The MAbs reacted with ganglioside GM<sub>1</sub> to different degrees, and these differences in fine specificities for GM<sub>1</sub> were reflected in the different degrees of reactivity with each of the <i>C. jejuni</i> LPSs tested. Antibodies could also be discriminated by the varying patterns of inhibition by cholera toxin (a GM<sub>1</sub> ligand) in LPS binding studies. These results indicate that there is a substantial heterogeneity among <i>C. jejuni</i> O:41 strains in their expression of GM<sub>1</sub>-like epitopes and among the fine specificities of different neuropathy-associated anti-GM<sub>1</sub> antibodies.
| Item Type: | Articles |
|---|---|
| Status: | Published |
| Refereed: | Yes |
| Glasgow Author(s) Enlighten ID: | Willison, Professor Hugh |
| Authors: | Prendergast, M.M., Willison, H.J., and Moran, A.P. |
| College/School: | College of Medical Veterinary and Life Sciences > School of Infection & Immunity |
| Journal Name: | Infection and Immunity |
| Journal Abbr.: | IAI |
| ISSN: | 0019-9567 |
| ISSN (Online): | 1098-5522 |
University Staff: Request a correction | Enlighten Editors: Update this record
Deposit and Record Details
Deposit and Record Details