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Randomized controlled trial of brain-derived neurotrophic factor in Guillain-Barré syndrome: a pilot study

Bensa, S., Hadden, R.D.M., Hahn, A., Hughes, R.A.C., and Willison, H.J. (2000) Randomized controlled trial of brain-derived neurotrophic factor in Guillain-Barré syndrome: a pilot study. European Journal of Neurology, 7 (4). pp. 423-426. ISSN 1351-5101 (doi:10.1046/j.1468-1331.2000.00096.x)

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Publisher's URL: http://dx.doi.org/10.1046/j.1468-1331.2000.00096.x

Abstract

Brain-derived neurotrophic factor (BDNF) has the theoretical potential to protect neurones from axonal degeneration. The objective of this study was to discover whether brain-derived neurotrophic factor is safe in Guillain-Barré syndrome, and to make preliminary observations of its efficacy. This was a parallel group randomized controlled trial of subcutaneous brain-derived neurotrophic factor 25 µ/kg daily compared with placebo for up to 24 weeks or until patients could walk without aid. Six patients received brain-derived neurotrophic factor, of whom three had serious adverse events including one death. Four patients received placebo, of whom two had serious adverse events including one death. The rate and extent of recovery were similar in the two groups. This pilot study did not detect any serious adverse events attributed to brain-derived neurotrophic factor treatment.

Item Type:Article
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Willison, Prof Hugh
Authors: Bensa, S., Hadden, R.D.M., Hahn, A., Hughes, R.A.C., and Willison, H.J.
College/School:College of Medical Veterinary and Life Sciences > Institute of Infection Immunity and Inflammation > Immunology
Journal Name:European Journal of Neurology
ISSN:1351-5101
ISSN (Online):1468-1331

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