Characterisation of the immunoglobulin variable region gene usage encoding the murine anti-ganglioside antibody repertoire

Boffey, J., Odaka, M., Nicoll, D., Wagner, E.R., Townson, K., Bowes, T., Conner, J., Furukawa, K. and Willison, H.J. (2005) Characterisation of the immunoglobulin variable region gene usage encoding the murine anti-ganglioside antibody repertoire. Journal of Neuroimmunology, 165(1-2), pp. 92-103. (doi:10.1016/j.jneuroim.2005.04.011)

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Publisher's URL: http://dx.doi.org/10.1016/j.jneuroim.2005.04.011

Abstract

Neuropathogenic murine antibodies reactive with terminal disialylgalactose epitopes are innate and preferentially encoded by the VH7183.3b gene. Here we have studied antibodies reactive with internal galactose-linked disialosyl epitopes and the terminal trisaccharide of GT1b. Antibodies were of moderate affinity and unmutated. Anti-GD1b antibodies were often encoded by the VH10.2b heavy and gj38c light chain genes. Anti-GT1b antibodies with broader glycan binding patterns were encoded by VHQ52 and VHJ558 family genes. These data indicate that the discrete specificities of ganglioside-binding antibodies are dictated by particular patterns of V gene usage residing within the innate B cell repertoire.

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Willison, Professor Hugh and Townson, Dr Kate
Authors: Boffey, J., Odaka, M., Nicoll, D., Wagner, E.R., Townson, K., Bowes, T., Conner, J., Furukawa, K., and Willison, H.J.
College/School:College of Medical Veterinary and Life Sciences > Institute of Infection Immunity and Inflammation
Journal Name:Journal of Neuroimmunology
ISSN:0165-5728
Published Online:20 June 2005

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