Boffey, J., Odaka, M., Nicoll, D., Wagner, E.R., Townson, K., Bowes, T., Conner, J., Furukawa, K. and Willison, H.J. (2005) Characterisation of the immunoglobulin variable region gene usage encoding the murine anti-ganglioside antibody repertoire. Journal of Neuroimmunology, 165(1-2), pp. 92-103. (doi: 10.1016/j.jneuroim.2005.04.011)
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Publisher's URL: http://dx.doi.org/10.1016/j.jneuroim.2005.04.011
Abstract
Neuropathogenic murine antibodies reactive with terminal disialylgalactose epitopes are innate and preferentially encoded by the <i>VH7183.3b</i> gene. Here we have studied antibodies reactive with internal galactose-linked disialosyl epitopes and the terminal trisaccharide of GT1b. Antibodies were of moderate affinity and unmutated. Anti-GD1b antibodies were often encoded by the <i>VH10.2b</i> heavy and <i>gj38c</i> light chain genes. Anti-GT1b antibodies with broader glycan binding patterns were encoded by VHQ52 and VHJ558 family genes. These data indicate that the discrete specificities of ganglioside-binding antibodies are dictated by particular patterns of V gene usage residing within the innate B cell repertoire.
Item Type: | Articles |
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Status: | Published |
Refereed: | Yes |
Glasgow Author(s) Enlighten ID: | Willison, Professor Hugh and Townson, Dr Kate |
Authors: | Boffey, J., Odaka, M., Nicoll, D., Wagner, E.R., Townson, K., Bowes, T., Conner, J., Furukawa, K., and Willison, H.J. |
College/School: | College of Medical Veterinary and Life Sciences > School of Infection & Immunity |
Journal Name: | Journal of Neuroimmunology |
ISSN: | 0165-5728 |
Published Online: | 20 June 2005 |
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