Treatment for Fisher syndrome, Bickerstaff's brainstem encephalitis and related disorders

Overell, J.R., Hsieh, S.-T., Odaka, M., Yuki, N. and Willison, H.J. (2007) Treatment for Fisher syndrome, Bickerstaff's brainstem encephalitis and related disorders. Cochrane Database of Systematic Reviews(1), CD004761. (doi:10.1002/14651858.CD004761.pub2)

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Publisher's URL: http://dx.doi.org/10.1002/14651858.CD004761.pub2

Abstract

Fisher syndrome is one of the regional variants of Guillain-Barré syndrome, characterised by impairment of eye movements (ophthalmoplegia), incoordination (ataxia) and loss of tendon reflexes (areflexia). It can occur in more limited forms, and may overlap with Guillain-Barré syndrome. A further variant is associated with upper motor neuron signs and disturbance of consciousness (Bickerstaff's brainstem encephalitis). All of these variants are associated with anti-GQ1b IgG antibodies. Intravenous immunoglobulin (IVIg) and plasma exchange are often used as treatments in this patient group. This review was undertaken to systematically assess any available randomised controlled data on acute immunomodulatory therapies in Fisher Syndrome or its variants.

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Overell, Dr James and Willison, Professor Hugh
Authors: Overell, J.R., Hsieh, S.-T., Odaka, M., Yuki, N., and Willison, H.J.
College/School:College of Medical Veterinary and Life Sciences > School of Medicine, Dentistry & Nursing
College of Medical Veterinary and Life Sciences > Institute of Infection Immunity and Inflammation
Journal Name:Cochrane Database of Systematic Reviews
ISSN:1469-493X
Published Online:20 January 2010

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