Mullen, W. , Gonzalez, J., Siwy, J., Franke, J., Sattar, N. , Mullan, A., Roberts, S., Delles, C. , Mischak, H. and Albalat, A. (2011) A pilot study on the effect of short-term consumption of a polyphenol rich drink on biomarkers of coronary artery disease defined by urinary proteomics. Journal of Agricultural and Food Chemistry, 59(24), pp. 12850-12857. (doi: 10.1021/jf203369r) (PMID:22070129)
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Abstract
Polyphenol rich diets have been associated with a reduced risk of cardiovascular disease. We examined the effect of a polyphenol rich (P-R) drink on biomarkers assessed by urinary proteomics. Thirty nine middle aged and overweight subjects were randomised to P-R drink (n=20) or placebo (n=19) in addition to their normal diet. After two weeks urine samples were obtained for assessment of the urinary proteome using capillary electrophoresis coupled to a mass spectrometer. A total of 93 polypeptides were found to be candidates for differential distribution with a nominal p-value<0.05, though these differences did not reach significance when multiple testing was accounted for. Sequences were determined in 19 of these demonstrating that they originate from alpha-1 antitrypsin, collagens, fibrinogen alpha and IgG kappa. Levels of 27 polypeptides were greater than 4-fold different between the two groups. Of these, 7 were previously found to be part of a coronary artery disease (CAD) specific urinary biomarker pattern. Their direction of expression was closer to the healthy state in the P-R drink group and closer to CAD state in the placebo group. Our data suggest that the P-R drink may have beneficial effects on urinary biomarkers of CAD. The data encourage the planning of future prospective studies, aiming at investigating significant effects of polyphenol rich dietary products.
| Item Type: | Articles |
|---|---|
| Status: | Published |
| Refereed: | Yes |
| Glasgow Author(s) Enlighten ID: | Albalat, Dr Amaya and Mullan, Dr Adam and Mullen, Dr Bill and Gonzalez, Dr Julien and Delles, Professor Christian and Mischak, Professor Harald and Sattar, Professor Naveed |
| Authors: | Mullen, W., Gonzalez, J., Siwy, J., Franke, J., Sattar, N., Mullan, A., Roberts, S., Delles, C., Mischak, H., and Albalat, A. |
| College/School: | College of Medical Veterinary and Life Sciences > School of Cardiovascular & Metabolic Health College of Medical Veterinary and Life Sciences > School of Life Sciences |
| Journal Name: | Journal of Agricultural and Food Chemistry |
| Publisher: | American Chemical Society |
| ISSN: | 0021-8561 |
| ISSN (Online): | 1520-5118 |
| Published Online: | 09 November 2011 |
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