Molecular genetic approaches for identifying the basis of variation in resistance to tick infestation in cattle

Porto Neto, L.R., Jonsson, N.N. , D’Occhio, M.J. and Barendse, W. (2011) Molecular genetic approaches for identifying the basis of variation in resistance to tick infestation in cattle. Veterinary Parasitology, 180(3-4), pp. 165-172. (doi:10.1016/j.vetpar.2011.05.048)

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Publisher's URL: http://dx.doi.org/10.1016/j.vetpar.2011.05.048

Abstract

In recent years there has been renewed interest in the adaptation of cattle to challenging environments, largely driven by advances in genomic methods. The current interest in tick resistance is understandable given the major production and welfare implications of tick infestation in tropical and subtropical zones where around 70% of beef cattle are located. Heritability for tick burden in cattle has been shown to range about 0.30, which is sufficient to result in the success of some programs of selection for tick resistance in cattle. Gene-expression studies strongly indicate that both immune and non-immune mechanisms are associated with tick resistance in cattle. Recent quantitative-trait mapping studies have identified chromosome segments and single nucleotide polymorphisms associated with tick burden, but no causal variant has been identified so far. Most of the genetic markers identified for tick burden explain a relatively small proportion of the variance, which is typical of markers for quantitative traits. This leads to the conclusion that panels of multiple markers for tick resistance rather than a single marker will most likely be developed, possibly involving specific panels for zebu or taurine breeds, which could be used for future selection and breeding programs in cattle.

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Jonsson, Professor Nicholas
Authors: Porto Neto, L.R., Jonsson, N.N., D’Occhio, M.J., and Barendse, W.
College/School:College of Medical Veterinary and Life Sciences > School of Veterinary Medicine
Journal Name:Veterinary Parasitology
ISSN:0304-4017
ISSN (Online):1873-2550
Published Online:01 June 2011

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