Marioni, R.E. et al. (2011) Genetic associations between fibrinogen and cognitive performance in three Scottish cohorts. Behavior Genetics, 41(5), pp. 691-699. (doi: 10.1007/s10519-011-9449-2)
Full text not currently available from Enlighten.
Abstract
There is increasing evidence to suggest that elevated plasma levels of fibrinogen are associated with late-life cognitive performance. This study tested the association of single nucleotide polymorphisms in the fibrinogen alpha (FGA) and beta (FGB) genes with cognitive performance. Data were analysed from three community-dwelling populations of older persons (> 50 years) in central Scotland: the Aspirin for Asymptomatic Atherosclerosis (AAA) Trial (n = 2,091), the Edinburgh Type 2 Diabetes Study (ET2DS, n = 1,066), and the Lothian Birth Cohort 1936 (LBC1936, n = 1,091). Cognition was assessed using a battery of five, seven, and four psychometric tests, respectively. This information was used to derive a general cognitive factor. Weakly significant associations were found between the rs4220 (FGB), and rs2227412 (FGB) SNPs and a single test of cognitive performance in the AAA Trial (p < 0.05). These findings did not replicate in the LBC1936 or ET2DS cohorts, except for the rs2227412 SNP, which was significantly associated with the general cognitive factor in the ET2DS (p = 3.3 x 10(-4)). A summary term that combined results from all three studies suggested that the rs2227412 genotype associated with reduced cognitive ability also associated with higher plasma fibrinogen levels. These findings suggest a tentative role for fibrinogen as a determinant of late-life cognitive performance and justify further attempts at replication in older persons.
Item Type: | Articles |
---|---|
Status: | Published |
Refereed: | Yes |
Glasgow Author(s) Enlighten ID: | Rumley, Dr Ann and Lowe, Professor Gordon |
Authors: | Marioni, R.E., Deary, I.J., Murray, G.D., Lowe, G.D.O., Strachan, M.W.J., Luciano, M., Houlihan, L.M., Gow, A.J., Harris, S.E., Rumley, A., Stewart, M.C., Fowkes, F.G.R., and Price, J.F. |
College/School: | College of Medical Veterinary and Life Sciences > School of Cardiovascular & Metabolic Health |
Journal Name: | Behavior Genetics |
ISSN: | 0001-8244 |
Published Online: | 23 January 2011 |
University Staff: Request a correction | Enlighten Editors: Update this record