MicroRNA and vascular remodelling in acute vascular injury and pulmonary vascular remodelling

McDonald, R. A., Hata, A., MacLean, M. R., Morrell, N. W. and Baker, A. H. (2012) MicroRNA and vascular remodelling in acute vascular injury and pulmonary vascular remodelling. Cardiovascular Research, 93(4), pp. 594-604. (doi:10.1093/cvr/cvr299)

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Publisher's URL: http://dx.doi.org/10.1093/cvr/cvr299

Abstract

Vascular remodelling is an integral pathological process central to a number of cardiovascular diseases. The complex interplay between distinct cell populations in the vessel wall following vascular injury leads to inflammation, cellular dysfunction, pro-growth signals in the smooth muscle cell compartment and the acquisition of a synthetic phenotype. Although the signals for vascular remodelling are diverse in different pathological contexts, smooth muscle cell proliferation and migration are consistently observed. It is therefore critical to elucidate key mechanisms central to these processes. microRNAs are small non-coding RNA that have the capacity to regulate many genes, pathways and complex biological networks within cells, acting either alone or in concert with one another. In diseases such as cancer and cardiac disease, the role of miRNA in disease pathogenesis has been documented in detail. In contrast, despite a great deal of interest in miRNA, relatively few studies have directly assessed the role of microRNA in vascular remodelling. The potential for modulation of microRNA to achieve therapeutic benefits in this setting is attractive. Here, we focus on the role of miRNA on vascular inflammation and remodelling associated with acute vascular injury (vein graft disease, angioplasty restenosis and in-stent restenosis) as well in the development of vascular remodelling associated with the development of pulmonary arterial hypertension

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:MacLean, Professor Margaret and Baker, Professor Andrew and McDonald, Dr Robert
Authors: McDonald, R. A., Hata, A., MacLean, M. R., Morrell, N. W., and Baker, A. H.
Subjects:R Medicine > RC Internal medicine
College/School:College of Medical Veterinary and Life Sciences > Institute of Cardiovascular and Medical Sciences
Journal Name:Cardiovascular Research
Journal Abbr.:Cardiovasc Res
Publisher:Oxford University Press
ISSN:0008-6363
ISSN (Online):1755-3245
Published Online:07 November 2011
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Project CodeAward NoProject NamePrincipal InvestigatorFunder's NameFunder RefLead Dept
519431Interrogation and manipulation of miRNA in acute vascular injuryAndrew BakerBritish Heart Foundation (BHF)RG/09/005/27915RI CARDIOVASCULAR & MEDICAL SCIENCES
573731Gender and the development of pulmonary arterial hypertension: regulation of genes from mouse to manMargaret MacleanBritish Heart Foundation (BHF)RG/11/7/28916RI CARDIOVASCULAR & MEDICAL SCIENCES
573733Gender and the development of pulmonary arterial hypertension: regulation of genes from mouse to manMargaret MacleanBritish Heart Foundation (BHF)RG/11/7/28916RI CARDIOVASCULAR & MEDICAL SCIENCES