McDonald, R. A., Hata, A., MacLean, M. R., Morrell, N. W. and Baker, A. H. (2012) MicroRNA and vascular remodelling in acute vascular injury and pulmonary vascular remodelling. Cardiovascular Research, 93(4), pp. 594-604. (doi: 10.1093/cvr/cvr299)
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Publisher's URL: http://dx.doi.org/10.1093/cvr/cvr299
Abstract
Vascular remodelling is an integral pathological process central to a number of cardiovascular diseases. The complex interplay between distinct cell populations in the vessel wall following vascular injury leads to inflammation, cellular dysfunction, pro-growth signals in the smooth muscle cell compartment and the acquisition of a synthetic phenotype. Although the signals for vascular remodelling are diverse in different pathological contexts, smooth muscle cell proliferation and migration are consistently observed. It is therefore critical to elucidate key mechanisms central to these processes. microRNAs are small non-coding RNA that have the capacity to regulate many genes, pathways and complex biological networks within cells, acting either alone or in concert with one another. In diseases such as cancer and cardiac disease, the role of miRNA in disease pathogenesis has been documented in detail. In contrast, despite a great deal of interest in miRNA, relatively few studies have directly assessed the role of microRNA in vascular remodelling. The potential for modulation of microRNA to achieve therapeutic benefits in this setting is attractive. Here, we focus on the role of miRNA on vascular inflammation and remodelling associated with acute vascular injury (vein graft disease, angioplasty restenosis and in-stent restenosis) as well in the development of vascular remodelling associated with the development of pulmonary arterial hypertension
| Item Type: | Articles |
|---|---|
| Status: | Published |
| Refereed: | Yes |
| Glasgow Author(s) Enlighten ID: | MacLean, Professor Margaret and Baker, Professor Andrew and McDonald, Dr Robert |
| Authors: | McDonald, R. A., Hata, A., MacLean, M. R., Morrell, N. W., and Baker, A. H. |
| Subjects: | R Medicine > RC Internal medicine |
| College/School: | College of Medical Veterinary and Life Sciences > School of Cardiovascular & Metabolic Health |
| Journal Name: | Cardiovascular Research |
| Journal Abbr.: | Cardiovasc Res |
| Publisher: | Oxford University Press |
| ISSN: | 0008-6363 |
| ISSN (Online): | 1755-3245 |
| Published Online: | 07 November 2011 |
| Related URLs: |
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