Alam, M., Takano, E. and Breitling, R. (2011) Prioritizing orphan proteins for further study using phylogenomics and gene expression profiles in Streptomyces coelicolor. BMC Research Notes, 4(1), p. 325. (doi: 10.1186/1756-0500-4-325)
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Publisher's URL: http://dx.doi.org/10.1186/1756-0500-4-325
Abstract
BACKGROUND:Streptomyces coelicolor, a model organism of antibiotic producing bacteria, has one of the largest genomes of the bacterial kingdom, including 7825 predicted protein coding genes. A large number of these genes, nearly 34%, are functionally orphan (hypothetical proteins with unknown function). However, in gene expression time course data, many of these functionally orphan genes show interesting expression patterns.RESULTS:In this paper, we analyzed all functionally orphan genes of Streptomyces coelicolor and identified a list of "high priority" orphans by combining gene expression analysis and additional phylogenetic information (i.e. the level of evolutionary conservation of each protein).CONCLUSIONS:The prioritized orphan genes are promising candidates to be examined experimentally in the lab for further characterization of their function
Item Type: | Articles |
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Status: | Published |
Refereed: | Yes |
Glasgow Author(s) Enlighten ID: | Breitling, Professor Rainer |
Authors: | Alam, M., Takano, E., and Breitling, R. |
College/School: | College of Medical Veterinary and Life Sciences > School of Molecular Biosciences |
Journal Name: | BMC Research Notes |
ISSN: | 1756-0500 |
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