Metabolomic analysis of trypanosomatid protozoa

Creek, D., Anderson, J. , McConville, M.J. and Barrett, M.P. (2012) Metabolomic analysis of trypanosomatid protozoa. Molecular and Biochemical Parasitology, 181(2), pp. 73-84. (doi:10.1016/j.molbiopara.2011.10.003)

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Metabolomics aims to measure all low molecular weight chemicals within a given system in a manner analogous to transcriptomics, proteomics and genomics. In this review we highlight metabolomics approaches that are currently being applied to the kinetoplastid parasites, Trypanosoma brucei and Leishmania spp. The use of untargeted metabolomics approaches, made possible through advances in mass spectrometry and informatics, and stable isotope labelling has increased our understanding of the metabolism in these organisms beyond the views established using classical biochemical approaches. Set within the context of metabolic networks, predicted using genome-wide reconstructions of metabolism, new hypothesises on how to target aspects of metabolism to design new drugs against these protozoa are emerging

Item Type:Articles
Glasgow Author(s) Enlighten ID:Anderson, Dr Jana and Barrett, Professor Michael and Creek, Dr Darren
Authors: Creek, D., Anderson, J., McConville, M.J., and Barrett, M.P.
College/School:College of Medical Veterinary and Life Sciences > Institute of Health and Wellbeing > Public Health
College of Medical Veterinary and Life Sciences > Institute of Infection Immunity and Inflammation
College of Medical Veterinary and Life Sciences > School of Life Sciences
Journal Name:Molecular and Biochemical Parasitology
Publisher:Elsevier BV
ISSN (Online):1872-9428

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