cAMP: Novel concepts in compartmentalised signalling

Edwards, H. V., Christian, F. and Baillie, G. S. (2012) cAMP: Novel concepts in compartmentalised signalling. Seminars in Cell and Developmental Biology, 23(2), pp. 181-190. (doi:10.1016/j.semcdb.2011.09.005)

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Publisher's URL: http://dx.doi.org/10.1016/j.semcdb.2011.09.005

Abstract

Cyclic adenosine 3,'5'-monophosphate (cAMP) is the archetypal second messenger produced at the membrane by adenylyl cyclase following activation of many different G protein-coupled receptor (GPCR) types. Although discovered over fifty years ago, the notion that cAMP responses were compartmentalised was born in the 1980s. Since then, modern molecular techniques have facilitated visualisation of cellular cAMP dynamics in real time and helped us to understand how a single, ubiquitous second messenger can direct receptor-specific functions in cells. The aim of this review is to highlight emerging ideas in the cAMP field that are currently developing the concept of compartmentalised cAMP signalling systems

Item Type:Articles
Keywords:cAMP, phosphodiesterase, Epac, PKA, receptor internalisation
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Baillie, Professor George and Christian, Dr Frank
Authors: Edwards, H. V., Christian, F., and Baillie, G. S.
Subjects:Q Science > QH Natural history > QH301 Biology
College/School:College of Medical Veterinary and Life Sciences > Institute of Neuroscience and Psychology
Journal Name:Seminars in Cell and Developmental Biology
Publisher:Elsevier
ISSN:1084-9521
ISSN (Online):1096-3634
Published Online:12 September 2011
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438301Phosphodiesterase-4 isoforms - intracellular targeting, regulation and potential therapeutic targetsMiles HouslayMedical Research Council (MRC)G0600765Institute of Neuroscience and Psychology
432501Transatlantic networks of excellence in cardiovascular diseaseMiles HouslayFoundation Leducq (LEDUCQ-VIL)06 CVD 02Institute of Neuroscience and Psychology