Intestinal macrophages - specialised adaptation to a unique environment

Bain, C.C. and Mowat, A.M. (2011) Intestinal macrophages - specialised adaptation to a unique environment. European Journal of Immunology, 41(9), pp. 2494-2498. (doi: 10.1002/eji.201141714)

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Publisher's URL: http://dx.doi.org/10.1002/eji.201141714

Abstract

Interest in intestinal mononuclear phagocytes (MPs), both DCs and macrophages (M phi s), has exploded in the recent years. In this Viewpoint we will detail how resident intestinal lamina propria (LP) M phi s possess distinctive properties that reflect adaptation to a unique microenvironment. They play quite different roles in the normal and inflamed mucosa and, as we will show, the existing paradigms of differentiated M phi subsets and of 'resident' versus 'inflammatory' monocytes based on other tissues may not apply to the gut. Strategies for targeting M phi s as a means of dampening intestinal inflammation will need to take account of these unique characteristics

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Mowat, Professor Allan
Authors: Bain, C.C., and Mowat, A.M.
College/School:College of Medical Veterinary and Life Sciences > Institute of Infection Immunity and Inflammation
Journal Name:European Journal of Immunology
ISSN:0014-2980

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