AMPK and vasculoprotection

Ewart, M.-A. and Kennedy, S. (2011) AMPK and vasculoprotection. Pharmacology and Therapeutics, 131(2), pp. 242-253. (doi: 10.1016/j.pharmthera.2010.11.002)

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AMP-activated protein kinase (AMPK) is proposed to be a key regulator of cellular and organismal metabolism and has reported vasculoprotective effects. In addition, many therapeutic agents used in the treatment of diabetes and atherosclerosis such as metformin, thiazolidinediones and statins may exert their vasculoprotective effects through activation of AMPK. Activation of AMPK has a number of potentially beneficial anti-atherosclerotic effects including reducing adhesion of inflammatory cells to the blood vessel endothelium, reducing lipid accumulation and the proliferation of inflammatory cells caused by oxidised lipids, stimulation of gene expression responsible for cellular antioxidant defenses and stimulation of enzymes responsible for nitric oxide formation. In humans and animals the AMPK cascade triggers vascular protective mechanisms that have been shown to reduce myocardial ischaemic injury and mutations in AMPK can cause familial hypertrophic cardiomyopathy. Taken together, these data suggest that activation and function of AMPK contributes to cardiovascular health. In this review we propose to focus on the vasculoprotective effects of AMPK, the evidence for AMPK activation with currently used therapeutic agents and the potential for agents which specifically activate AMPK as a treatment for vascular disease.

Item Type:Articles
Glasgow Author(s) Enlighten ID:Kennedy, Professor Simon and Ewart, Dr Marie-Ann
Authors: Ewart, M.-A., and Kennedy, S.
Subjects:R Medicine > RM Therapeutics. Pharmacology
College/School:College of Medical Veterinary and Life Sciences > Institute of Cardiovascular and Medical Sciences
Journal Name:Pharmacology and Therapeutics
Journal Abbr.:Pharmacol. Ther.
ISSN (Online):1879-016X
Published Online:25 November 2010
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Project CodeAward NoProject NamePrincipal InvestigatorFunder's NameFunder RefLead Dept
547511Involvement of AMPK in calcium regulation in atherosclerotic blood vessels.Marie-Ann EwartBritish Heart Foundation (BHF)PG/10/70/28384RI CARDIOVASCULAR & MEDICAL SCIENCES