Accelerated telomere attrition is associated with relative household income, diet and inflammation in the pSoBid cohort

Shiels, P.G. et al. (2011) Accelerated telomere attrition is associated with relative household income, diet and inflammation in the pSoBid cohort. PLoS ONE, 6(7), e22521. (doi:10.1371/journal.pone.0022521)

Shiels, P.G. et al. (2011) Accelerated telomere attrition is associated with relative household income, diet and inflammation in the pSoBid cohort. PLoS ONE, 6(7), e22521. (doi:10.1371/journal.pone.0022521)

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Abstract

BACKGROUND: It has previously been hypothesized that lower socio-economic status can accelerate biological ageing, and predispose to early onset of disease. This study investigated the association of socio-economic and lifestyle factors, as well as traditional and novel risk factors, with biological-ageing, as measured by telomere length, in a Glasgow based cohort that included individuals with extreme socio-economic differences. <br></br> <br></br> METHODS: A total of 382 blood samples from the pSoBid study were available for telomere analysis. For each participant, data was available for socio-economic status factors, biochemical parameters and dietary intake. Statistical analyses were undertaken to investigate the association between telomere lengths and these aforementioned parameters. <br></br> <br></br> RESULTS: The rate of age-related telomere attrition was significantly associated with low relative income, housing tenure and poor diet. Notably, telomere length was positively associated with LDL and total cholesterol levels, but inversely correlated to circulating IL-6. <br></br> <br></br> CONCLUSIONS: These data suggest lower socio-economic status and poor diet are relevant to accelerated biological ageing. They also suggest potential associations between elevated circulating IL-6, a measure known to predict cardiovascular disease and diabetes with biological ageing. These observations require further study to tease out potential mechanistic links.

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:McConnachie, Dr Alex and Johnson, Dr Paul and Ford, Professor Ian and Tannahill, Dr Carol and Shiels, Professor Paul and Millar, Professor Keith and Cavanagh, Professor Jonathan and Velupillai, Dr Yoganathan and McGlynn, Dr Liane and Batty, Dr G and Packard, Professor Chris and Sattar, Professor Naveed
Authors: Shiels, P.G., McGlynn, L.M., MacIntyre, A., Johnson, P.C.D., Batty, G.D., Burns, H., Cavanagh, J., Deans, K.A., Ford, I., McConnachie, A., McGinty, A., McLean, J.S., Millar, K., Sattar, N., Tannahill, C., Velupillai, Y.N., and Packard, C.J.
Subjects:R Medicine > RA Public aspects of medicine
College/School:College of Medical Veterinary and Life Sciences > Institute of Health and Wellbeing > Robertson Centre
College of Medical Veterinary and Life Sciences > Institute of Health and Wellbeing > Mental Health and Wellbeing
College of Medical Veterinary and Life Sciences > Institute of Cancer Sciences
College of Medical Veterinary and Life Sciences > Institute of Cardiovascular and Medical Sciences
College of Medical Veterinary and Life Sciences > School of Medicine, Dentistry & Nursing
Journal Name:PLoS ONE
Publisher:Public Library of Science
ISSN:1932-6203
ISSN (Online):1932-6203
Published Online:27 July 2011
Copyright Holders:Copyright © 2011 Public Library of Science
First Published:First published in PLoS ONE 6(7):e22521
Publisher Policy:Reproduced in accordance with the copyright policy of the publisher
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