Cross-bridge apparent rate constants of human gallbladder smooth muscle

Li, W.G., Luo, X.Y. , Hill, N.A. , Ogden, R.W. , Tian, T.H., Smythe, A., Majeed, A.W. and Bird, N. (2011) Cross-bridge apparent rate constants of human gallbladder smooth muscle. Journal of Muscle Research and Cell Motility, 32(3), pp. 209-220. (doi:10.1007/s10974-011-9260-y)

Full text not currently available from Enlighten.

Publisher's URL: http://dx.doi.org/10.1007/s10974-011-9260-y

Abstract

This paper studies human gallbladder (GB) smooth muscle contractions. A two-state cross-bridge model was used to estimate the apparent attachment and detachment rate constants, as well as increased Ca(2+) concentration from the peak active stress during the isometric contraction. The active stress was computed from a mechanical model based entirely on non-invasive routine ultrasound scans. In the two-state cross-bridge model, the two apparent rate constants, representing the total attached/detached cross-bridges, respectively, were estimated using active stress prediction for 51 subjects undergoing cholecystokinin-provocation test, together with estimates from the four-state cross-bridge model for a swine carotid, bovine tracheal and guinea pig GB smooth muscles. The study suggests that the apparent rate constants should be patient-specific, i.e. patients with a lower stress level are characterized by smaller apparent rate constants. In other words, the diseased GB may need to develop fast cycling cross-bridges to compensate in the emptying process. This is a first step towards more quantitative and non-invasive measures of GB pain, and may provide useful insight in understanding GB motility and developing effective drug treatments.

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Luo, Professor Xiaoyu and Hill, Professor Nicholas and Li, Dr Wenguang and Ogden, Professor Raymond and Tian, Dr Tianhai
Authors: Li, W.G., Luo, X.Y., Hill, N.A., Ogden, R.W., Tian, T.H., Smythe, A., Majeed, A.W., and Bird, N.
College/School:College of Science and Engineering > School of Mathematics and Statistics > Mathematics
Journal Name:Journal of Muscle Research and Cell Motility
Publisher:Springer Verlag
ISSN:0142-4319
ISSN (Online):1573-2657
Published Online:27 September 2011
Related URLs:

University Staff: Request a correction | Enlighten Editors: Update this record

Project CodeAward NoProject NamePrincipal InvestigatorFunder's NameFunder RefLead Dept
489101Exploring the Mechanisms of Human Gallbladder PainXiaoyu LuoEngineering & Physical Sciences Research Council (EPSRC)EP/G015651/1M&S - MATHEMATICS