Ability of antibodies to two new caliciviral vaccine strains to neutralise feline calicivirus isolates from the UK

Addie, D., Poulet, H., Golder, M.C., McDonald, M., Brunet, S., Thibault, J.-C. and Hosie, M.J. (2008) Ability of antibodies to two new caliciviral vaccine strains to neutralise feline calicivirus isolates from the UK. Veterinary Record, 163(12), pp. 355-7. (doi:10.1136/vr.163.12.355)

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Publisher's URL: http://dx.doi.org/10.1136/vr.163.12.355

Abstract

This study examined a panel of 110 UK field isolates of feline calicivirus (FCV) for susceptibility to cross-neutralisation by a panel of eight antisera raised in cats infected with FCV strains F9, 255, FCVG1 and FCV431. The pairs of antisera raised against F9 or 255, neutralised 20 and 21 per cent or 37 and 56 per cent of field strains of virus respectively. In contrast, the pairs of antisera raised against the newer vaccine strains FCVG1 or FCV431 neutralised 29 and 70 per cent or 67 and 87 per cent of field strains respectively. Antisera raised against the two newer strains, namely FCVG1 and FCV431, neutralised a greater proportion of field strains of calicivirus than antisera raised against the older FCV vaccine strains F9 and 255.

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Hosie, Professor Margaret and McDonald, Mr Michael and Golder, Mr Matthew and Addie, Dr Diane
Authors: Addie, D., Poulet, H., Golder, M.C., McDonald, M., Brunet, S., Thibault, J.-C., and Hosie, M.J.
Subjects:Q Science > QR Microbiology > QR355 Virology
College/School:College of Medical Veterinary and Life Sciences > School of Medicine, Dentistry & Nursing
College of Medical Veterinary and Life Sciences > School of Veterinary Medicine
College of Medical Veterinary and Life Sciences > Institute of Infection Immunity and Inflammation
Journal Name:Veterinary Record
Publisher:B M J Group
ISSN:0042-4900
ISSN (Online):2042-7670
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Project CodeAward NoProject NamePrincipal InvestigatorFunder's NameFunder RefLead Dept
363381Rational Design of a Lentiviral VaccineMargaret HosieMedical Research Council (MRC)G0300387Centre for Virus Research