The genetics of cardiovascular disease

Delles, C., McBride, M.W., Padmanabhan, S. and Dominiczak, A.F. (2008) The genetics of cardiovascular disease. Trends in Endocrinology and Metabolism, 19(9), pp. 309-316. (doi:10.1016/j.tem.2008.07.010)

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Publisher's URL: http://dx.doi.org/10.1016/j.tem.2008.07.010

Abstract

Recent advances in genotyping technology and insights into disease mechanisms have increased interest in the genetics of cardiovascular disease. Several candidate genes involved in cardiovascular diseases were identified from studies using animal models, and the translation of these findings to human disease is an exciting challenge. There is a trend towards large-scale genome-wide association studies that are subject to strict quality criteria with regard to both genotyping and phenotyping. Here, we review some of the strategies that have been developed to translate findings from experimental models to human disease and outline the need for optimizing global approaches to analyze such results. Findings from ongoing studies are interpreted in the context of disease pathways instead of the more traditional focus on single genetic variants.

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:McBride, Dr Martin and Padmanabhan, Professor Sandosh and Dominiczak, Professor Anna and Delles, Professor Christian
Authors: Delles, C., McBride, M.W., Padmanabhan, S., and Dominiczak, A.F.
Subjects:R Medicine > RC Internal medicine
College/School:College of Medical Veterinary and Life Sciences > Institute of Cardiovascular and Medical Sciences
College of Medical Veterinary and Life Sciences > Institute of Cardiovascular and Medical Sciences
College of Medical Veterinary and Life Sciences > Institute of Cardiovascular and Medical Sciences
College of Medical Veterinary and Life Sciences > Institute of Cardiovascular and Medical Sciences
College of Medical Veterinary and Life Sciences > Institute of Cardiovascular and Medical Sciences
College of Medical Veterinary and Life Sciences
Journal Name:Trends in Endocrinology and Metabolism
Publisher:Elsevier
ISSN:1043-2760
Copyright Holders:Copyright © 2008 Elsevier
First Published:First published in Trends in Endocrinology & Metabolism 19(9):309-316
Publisher Policy:Reproduced in accordance with the copyright policy of the publisher.

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