Building a new conceptual framework for receptor heteromers

Ferre, S. et al. (2009) Building a new conceptual framework for receptor heteromers. Nature Chemical Biology, 5(3), pp. 131-134. (doi: 10.1038/nchembio0309-131)

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Publisher's URL: http://dx.doi.org/10.1038/nchembio0309-131

Abstract

Receptor heteromers constitute a new area of research that is reshaping our thinking about biochemistry, cell biology, pharmacology and drug discovery. In this commentary, we recommend clear definitions that should facilitate both information exchange and research on this growing class of transmembrane signal transduction units and their complex properties. We also consider research questions underlying the proposed nomenclature, with recommendations for receptor heteromer identification in native tissues and their use as targets for drug development.

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Milligan, Professor Graeme
Authors: Ferre, S., Baler, R., Bouvier, M., Caron, M. G., Devi, L. A., Durroux, T., Fuxe, K., George, S. R., Javitch, J. A., Lohse, M. J., Mackie, K., Milligan, G., Pfleger, K. D.G., Pin, J.-P., Volkow, N. D., Waldhoer, M., Woods, A. S., and Franco, R.
Subjects:Q Science > QH Natural history > QH345 Biochemistry
College/School:College of Medical Veterinary and Life Sciences > Institute of Neuroscience and Psychology
Journal Name:Nature Chemical Biology
Publisher:Nature Publishing Group
ISSN:1552-4450
ISSN (Online):1552-4469
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Project CodeAward NoProject NamePrincipal InvestigatorFunder's NameFunder RefLead Dept
242491Quantitative Analysis of the Effects of Receptor and G-Protein Mutations and Polymorphisms on Signal InitiationGraeme MilliganMedical Research Council (MRC)G9811527Institute of Neuroscience and Psychology
242492Quantitative Analysis of the Effects of Receptor and G-Protein Mutations and Polymorphisms on Signal InitiationGraeme MilliganMedical Research Council (MRC)G9811527Institute of Neuroscience and Psychology
389781The quaternary structure of G-protein coupled receptors - implications for function drug design. Programme grant support renewalGraeme MilliganMedical Research Council (MRC)G9811527Institute of Neuroscience and Psychology