Modulation of epithelial innate immunity by autocrine production of nitric oxide

Davies, S.A. and Dow, J.A.T. (2009) Modulation of epithelial innate immunity by autocrine production of nitric oxide. General and Comparative Endocrinology, 162(1), pp. 113-121. (doi: 10.1016/j.ygcen.2008.09.012) (PMID:18952086)

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Mechanisms of innate immunity especially with relevance to epithelial tissue, are currently the focus of intense research, as epithelial immunity greatly impacts on health and disease. However, many findings regarding innate immunity signalling pathways in vertebrates stems from research using the genetic model <i>Drosophila melanogaster</i>. Here we discuss the central importance of epithelial tissues in innate immunity in <i>Drosophila</i>; the modulation of the Imd pathway via autocrine production of nitric oxide (NO); and the central importance of the Malpighian (renal) tubule in immune function of the whole animal.

Item Type:Articles
Keywords:Innate immunity, drosophila, secretory epithelia, malpighian tubules autocrine, nitric oxide
Glasgow Author(s) Enlighten ID:Dow, Professor Julian and Davies, Professor Shireen
Authors: Davies, S.A., and Dow, J.A.T.
Subjects:Q Science > QP Physiology
Q Science > QH Natural history > QH426 Genetics
College/School:College of Medical Veterinary and Life Sciences > Institute of Molecular Cell and Systems Biology
Journal Name:General and Comparative Endocrinology
Publisher:Elsevier BV

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Project CodeAward NoProject NamePrincipal InvestigatorFunder's NameFunder RefLead Dept
325421Affymetrix array service for the UK Drosophila CommunityJulian DowBiotechnology and Biological Sciences Research Council (BBSRC)17/G17767Institute of Molecular Cell and Systems Biology