Davies, S.A. and Dow, J.A.T. (2009) Modulation of epithelial innate immunity by autocrine production of nitric oxide. General and Comparative Endocrinology, 162(1), pp. 113-121. (doi: 10.1016/j.ygcen.2008.09.012) (PMID:18952086)
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Publisher's URL: http://dx.doi.org/10.1016/j.ygcen.2008.09.012
Abstract
Mechanisms of innate immunity especially with relevance to epithelial tissue, are currently the focus of intense research, as epithelial immunity greatly impacts on health and disease. However, many findings regarding innate immunity signalling pathways in vertebrates stems from research using the genetic model <i>Drosophila melanogaster</i>. Here we discuss the central importance of epithelial tissues in innate immunity in <i>Drosophila</i>; the modulation of the Imd pathway via autocrine production of nitric oxide (NO); and the central importance of the Malpighian (renal) tubule in immune function of the whole animal.
Item Type: | Articles |
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Keywords: | Innate immunity, drosophila, secretory epithelia, malpighian tubules autocrine, nitric oxide |
Status: | Published |
Refereed: | Yes |
Glasgow Author(s) Enlighten ID: | Dow, Professor Julian and Davies, Professor Shireen |
Authors: | Davies, S.A., and Dow, J.A.T. |
Subjects: | Q Science > QP Physiology Q Science > QH Natural history > QH426 Genetics |
College/School: | College of Medical Veterinary and Life Sciences > School of Molecular Biosciences |
Journal Name: | General and Comparative Endocrinology |
Publisher: | Elsevier BV |
ISSN: | 0016-6480 |
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