Brennan, K.M. et al. (2011) Lipid arrays identify myelin-derived lipids and lipid complexes as prominent targets for oligoclonal band antibodies in multiple sclerosis. Journal of Neuroimmunology, 238 (1-2). pp. 87-95. ISSN 0165-5728 (doi:10.1016/j.jneuroim.2011.08.002)
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Publisher's URL: http://dx.doi.org/10.1016/j.jneuroim.2011.08.002
The presence of oligoclonal bands of IgG (OCB) in cerebrospinal fluid (CSF) is used to establish a diagnosis of multiple sclerosis (MS), but their specificity has remained an enigma since its first description over forty years ago. We now report that the use of lipid arrays identifies heteromeric complexes of myelin derived lipids as a prominent target for this intrathecal B cell response.
|Glasgow Author(s):||Elliott, Dr Christina and O'Leary, Dr Colin and Willison, Prof Hugh and Barnett, Prof Susan and Kalna, Dr Gabriela and Arthur, Dr Ariel and Linington, Prof Christopher and Rinaldi, Dr Simon and Goodyear, Dr Carl|
|Authors:||Brennan, K.M., Galban-Horcajo, F., Rinaldi, S., O'Leary, C.P., Goodyear, C.S., Kalna, G., Arthur, A., Elliott, C., Barnett, S., Linington, C., Bennett, J.L., Owens, G.P., and Willison, H.J.|
|College/School:||College of Medical Veterinary and Life Sciences > Institute of Cancer Sciences > Beatson Institute of Cancer Research|
College of Medical Veterinary and Life Sciences > Institute of Infection Immunity and Inflammation
College of Medical Veterinary and Life Sciences > School of Medicine
|Journal Name:||Journal of Neuroimmunology|