Lipid arrays identify myelin-derived lipids and lipid complexes as prominent targets for oligoclonal band antibodies in multiple sclerosis

Brennan, K.M. et al. (2011) Lipid arrays identify myelin-derived lipids and lipid complexes as prominent targets for oligoclonal band antibodies in multiple sclerosis. Journal of Neuroimmunology, 238(1-2), pp. 87-95. (doi:10.1016/j.jneuroim.2011.08.002)

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Publisher's URL: http://dx.doi.org/10.1016/j.jneuroim.2011.08.002

Abstract

The presence of oligoclonal bands of IgG (OCB) in cerebrospinal fluid (CSF) is used to establish a diagnosis of multiple sclerosis (MS), but their specificity has remained an enigma since its first description over forty years ago. We now report that the use of lipid arrays identifies heteromeric complexes of myelin derived lipids as a prominent target for this intrathecal B cell response.

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Willison, Professor Hugh and Barnett, Professor Susan and Linington, Professor Christopher and Goodyear, Professor Carl and Elliott, Dr Christina and O'Leary, Dr Colin and Kalna, Dr Gabriela and Arthur, Dr Ariel and Rinaldi, Dr Simon
Authors: Brennan, K.M., Galban-Horcajo, F., Rinaldi, S., O'Leary, C.P., Goodyear, C.S., Kalna, G., Arthur, A., Elliott, C., Barnett, S., Linington, C., Bennett, J.L., Owens, G.P., and Willison, H.J.
College/School:College of Medical Veterinary and Life Sciences > Institute of Cancer Sciences
Journal Name:Journal of Neuroimmunology
ISSN:0165-5728

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