Lipid arrays identify myelin-derived lipids and lipid complexes as prominent targets for oligoclonal band antibodies in multiple sclerosis

Brennan, K.M. et al. (2011) Lipid arrays identify myelin-derived lipids and lipid complexes as prominent targets for oligoclonal band antibodies in multiple sclerosis. Journal of Neuroimmunology, 238(1-2), pp. 87-95. (doi: 10.1016/j.jneuroim.2011.08.002)

Abstract

The presence of oligoclonal bands of IgG (OCB) in cerebrospinal fluid (CSF) is used to establish a diagnosis of multiple sclerosis (MS), but their specificity has remained an enigma since its first description over forty years ago. We now report that the use of lipid arrays identifies heteromeric complexes of myelin derived lipids as a prominent target for this intrathecal B cell response.

• Item Type: Articles
• Status: Published
• Refereed: Yes
• Glasgow Author(s) Enlighten ID: Elliott, Dr Christina and O'Leary, Dr Colin and Willison, Professor Hugh and Barnett, Professor Susan and Kalna, Dr Gabriela and Arthur, Dr Ariel and Linington, Professor Christopher and Rinaldi, Dr Simon and Goodyear, Professor Carl
• Authors: Brennan, K.M., Galban-Horcajo, F., Rinaldi, S., O'Leary, C.P., Goodyear, C.S., Kalna, G., Arthur, A., Elliott, C., Barnett, S., Linington, C., Bennett, J.L., Owens, G.P., and Willison, H.J.
• College/School: College of Medical Veterinary and Life Sciences > School of Cancer Sciences
• Journal Name: Journal of Neuroimmunology
• ISSN: 0165-5728