The effect of nonsteroidal anti-inflammatory drugs on the equine intestine

Marshall, J.F. and Blikslager, A.T. (2011) The effect of nonsteroidal anti-inflammatory drugs on the equine intestine. Equine Veterinary Journal, 43(S39), pp. 140-144. (doi:10.1111/j.2042-3306.2011.00398.x)

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Publisher's URL: http://dx.doi.org/10.1111/j.2042-3306.2011.00398.x

Abstract

Nonsteroidal anti-inflammatory drugs (NSAIDs) are commonly used in the management of pain and endotoxaemia associated with colic in the horse. While NSAIDs effectively treat the symptoms of colic, there is evidence to suggest that their administration is associated with adverse gastrointestinal effects including right dorsal colitis and inhibition of mucosal barrier healing. Several studies have examined the pathophysiology of NSAID associated effects on the large and small intestine in an effort to avoid these complications and identify effective alternative medications. Differences in the response of the large and small intestines to injury and NSAID treatment have been identified. Flunixin meglumine has been shown in the small intestine to inhibit barrier function recovery and increase permeability to lipopolysaccharide (LPS). A range of NSAIDs has been examined in the small intestine and experimental evidence suggests that those NSAIDs with cyclooxygenase independent anti-inflammatory effects or a COX-2 selective mode of action may offer significant advantages over traditional NSAIDs

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Marshall, Dr John
Authors: Marshall, J.F., and Blikslager, A.T.
College/School:College of Medical Veterinary and Life Sciences > School of Veterinary Medicine
Journal Name:Equine Veterinary Journal
Publisher:Equine Veterinary Journal Ltd
ISSN:0425-1644

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