Fibroblast growth factor 23 predicts left ventricular mass and induces cell adhesion molecule formation

Stevens, K.K., McQuarrie, E.P., Sands, W., Hillyard, D.Z., Patel, R.K., Mark, P.B. and Jardine, A.G. (2011) Fibroblast growth factor 23 predicts left ventricular mass and induces cell adhesion molecule formation. International Journal of Nephrology, 2011(297070), pp. 1-6. (doi:10.4061/2011/297070)

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Publisher's URL: http://dx.doi.org/10.4061/2011/297070

Abstract

Elevated FGF-23 is a predictor of mortality and is associated with LVH in CKD. It may be a biomarker or a direct toxin. We assessed the relationship between FGF-23 and LVH in CKD using CMRI. In vitro we studied the effect of phosphate, FGF-23, and Klotho on E-selectin and VCAM production in HUVECs. FGF-23 concentration correlates negatively with eGFR and positively with LVMI. FGF-23 was an independent predictor of LVH in CKD. E-selectin and VCAM production was elevated in HUVECs cultured in high phosphate with FGF-23 or Klotho. This effect was attenuated in cells exposed to both FGF-23 and Klotho. FGF-23 is an independent predictor of LVH as measured by CMRI. We show preliminary data which supports that FGF-23 is toxic resulting in activation of the vascular endothelium. We do not prove causality with elevated FGF-23 and LVH. Further research should ascertain if lowering levels of FGF-23 translates to improved clinical outcomes.

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Patel, Dr Rajan and McQuarrie, Dr Emily and Stevens, Dr Kate and Mark, Dr Patrick and Sands, Dr William and Hillyard, Ms Dianne and Jardine, Professor Alan
Authors: Stevens, K.K., McQuarrie, E.P., Sands, W., Hillyard, D.Z., Patel, R.K., Mark, P.B., and Jardine, A.G.
Subjects:R Medicine > RC Internal medicine
College/School:College of Medical Veterinary and Life Sciences > Institute of Cardiovascular and Medical Sciences
College of Medical Veterinary and Life Sciences > Institute of Cancer Sciences
Journal Name:International Journal of Nephrology
ISSN:2090-2158
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