Bronchial nitric oxide flux (J′aw) is sensitive to oral corticosteroids in smokers with asthma

Spears, M., Weir, C.J., Smith, A.D., McSharry, C., Chaudhuri, R., Johnson, M., Cameron, E. and Thomson, N.C. (2011) Bronchial nitric oxide flux (J′aw) is sensitive to oral corticosteroids in smokers with asthma. Respiratory Medicine, 105(12), pp. 1823-1830. (doi: 10.1016/j.rmed.2011.06.014)

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Publisher's URL: http://dx.doi.org/10.1016/j.rmed.2011.06.014

Abstract

Background: Exhaled nitric oxide provides a convenient, non-invasive insight into airway inflammation. However it is suppressed by current smoking, reducing its potential as an endpoint in studies of smokers with asthma, a group with increased symptoms and poor clinical responses to corticosteroids. We examined extended nitric oxide analysis as some derived variables are thought to be unaffected. Therefore this approach could reveal hidden inflammation and enable its use as an exploratory endpoint in this group. Results: FE<sub>NO50</sub> was significantly lower in smokers with asthma and did not change significantly in response to dexamethasone. C<sub>alv</sub> derived by linear modelling was lower in smokers with asthma and did not change significantly in response in either group. J′<sub>aw</sub> was substantially lower in smokers with asthma (smokers (median (IQR)); 573 pl/s (217, 734), non-smoker; 1535 pl/s (785, 3496), p = 0.001) and was reduced in both groups following dexamethasone (non-smokers change (mean (95% CI)); −743.3 pl/s (−1710, −163), p = 0.005, smokers; −293 pl/s (−572, −60), p = 0.016). Correction for axial flow did not substantially change the derived results. Conclusions: Bronchial NO flux appears to be sensitive to oral dexamethasone and may provide a useful exploratory endpoint for the analysis of novel anti-inflammatory therapies in smokers with asthma.

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Thomson, Professor Neil and Cameron, Dr Euan and Weir, Christopher and Spears, Dr Mark and Chaudhuri, Dr Rekha and McSharry, Dr Charles
Authors: Spears, M., Weir, C.J., Smith, A.D., McSharry, C., Chaudhuri, R., Johnson, M., Cameron, E., and Thomson, N.C.
Subjects:R Medicine > RC Internal medicine
College/School:College of Medical Veterinary and Life Sciences > Institute of Infection Immunity and Inflammation
College of Medical Veterinary and Life Sciences > Institute of Health and Wellbeing > Robertson Centre
College of Medical Veterinary and Life Sciences > School of Medicine, Dentistry & Nursing
Journal Name:Respiratory Medicine
Publisher:Elsevier Ltd
ISSN:0954-6111
ISSN (Online):1532-3064
Published Online:12 August 2011

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