Enlighten
Research publications by members of the University of Glasgow
home > services > Enlighten

Angiotensin II levels, hemodynamics and sympathoadrenal function after low-dose Captopril in heart failure

Cleland , J., Semple, P., Ball, S., Ford, I., Dargie, H., and Hodsman, P. (1984) Angiotensin II levels, hemodynamics and sympathoadrenal function after low-dose Captopril in heart failure. American Journal of Medicine , 77 (5). pp. 880-886. ISSN 0002-9343 (doi:10.1016/0002-9343(84)90530-8)

Full text not currently available from Enlighten.

Publisher's URL: http://dx.doi.org/10.1016/0002-9343(84)90530-8

Abstract

The anglotensin converting enzyme inhibitor captopril improves the altered hemodynamics in many patients with chronic heart failure, but the first dose may precipitate hypotension. Ten patients with chronic heart failure were studied, nine with high plasma concentrations of renin and one with a low concentration. Frequent measurements of plasma concentrations of angiotensin II, renin, and catecholamines were made over 60 minutes after a small dose (6.25 mg) of captopril and related to concurrently measured hemodynamic variables. Captopril caused a decrease in systemic and pulmonary artery pressure and an increase in cardiac index, and these changes coincided with reductions in the plasma concentrations of angiotensin II and increases in plasma concentrations of renin. The hemodynamic changes were accompanied by reductions in the plasma concentrations of norepinephrine but transient increases in plasma concentrations of epinephrine in patients in whom vasomotor syncope developed. The patient with a low plasma renin concentration showed little hemodynamic response to the drug. It is concluded that vasomotor syncope occurs quite frequently in patients with severe chronic heart failure after captoprll in a small dose and is associated with a selective increase in epinephrine secretion from the adrenal medulla.

Item Type:Article
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Semple, Dr Peter and Ford, Prof Ian and Dargie, Prof Henry
Authors: Cleland , J., Semple, P., Ball, S., Ford, I., Dargie, H., and Hodsman, P.
Subjects:R Medicine > R Medicine (General)
College/School:College of Medical Veterinary and Life Sciences > Institute of Cardiovascular and Medical Sciences
College of Medical Veterinary and Life Sciences > Institute of Health and Wellbeing > Robertson Centre
Journal Name:American Journal of Medicine
Publisher:Elsevier
ISSN:0002-9343
ISSN (Online):1555-7162
Published Online:19 March 2004

University Staff: Request a correction | Enlighten Editors: Update this record