Genetically divergent strains of feline immunodeficiency virus from the domestic cat (Felis catus) and the African lion (Panthera leo) share usage of CD134 and CXCR4 as entry receptors

McEwan, W. A., McMonagle, E. L., Logan, N., Serra, R. C., Kat, P., Vandewoude, S., Hosie, M. J. and Willett, B. J. (2008) Genetically divergent strains of feline immunodeficiency virus from the domestic cat (Felis catus) and the African lion (Panthera leo) share usage of CD134 and CXCR4 as entry receptors. Journal of Virology, 82(21), pp. 10953-10958. (doi:10.1128/JVI.01312-08)

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Publisher's URL: http://dx.doi.org/10.1128/JVI.01312-08

Abstract

The <i>env</i> open reading frames of African lion (<i>Panthera leo</i>) lentivirus (feline immunodeficiency virus [FIV(<sub>Ple</sub>)]) subtypes B and E from geographically distinct regions of Africa suggest two distinct ancestries, with FIV(<sub>Ple</sub>)-E sharing a common ancestor with the domestic cat (<i>Felis catus</i>) lentivirus (FIV(<sub>Fca</sub>)). Here we demonstrate that FIV(<sub>Ple</sub>)-E and FIV(<sub>Fca</sub>) share the use of CD134 (OX40) and CXCR4 as a primary receptor and coreceptor, respectively, and that both lion CD134 and CXCR4 are functional receptors for FIV(<sub>Ple</sub>)-E. The shared usage of CD134 and CXCR4 by FIV(<sub>Fca</sub>) and FIV(<sub>Ple</sub>)-E may have implications for in vivo cell tropism and the pathogenicity of the E subtype among free-ranging lion populations.

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Hosie, Professor Margaret and Willett, Professor Brian and McMonagle, Mrs Elizabeth and Logan, Miss Nicola
Authors: McEwan, W. A., McMonagle, E. L., Logan, N., Serra, R. C., Kat, P., Vandewoude, S., Hosie, M. J., and Willett, B. J.
Subjects:Q Science > QL Zoology
Q Science > QR Microbiology > QR355 Virology
College/School:College of Medical Veterinary and Life Sciences > Institute of Infection Immunity and Inflammation
Journal Name:Journal of Virology
Journal Abbr.:J. Virol.
Publisher:American Society for Microbiology
ISSN:0022-538X
ISSN (Online):1098-5514
Published Online:20 August 2008
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Project CodeAward NoProject NamePrincipal InvestigatorFunder's NameFunder RefLead Dept
363381Rational Design of a Lentiviral VaccineMargaret HosieMedical Research Council (MRC)G0300387/66515Centre for Virus Research