Investigating human audio-visual object perception with a combination of hypothesis-generating and hypothesis-testing fMRI analysis tools

Naumer, M.J., van den Bosch, J., Wibral, M., Kohler, A., Singer, W., Kaiser, J., van de Ven, V. and Muckli, L. (2011) Investigating human audio-visual object perception with a combination of hypothesis-generating and hypothesis-testing fMRI analysis tools. Experimental Brain Research, 213(2-3), pp. 309-320. (doi: 10.1007/s00221-011-2669-0)

[img]
Preview
Text
54890.pdf

387kB

Abstract

Primate multisensory object perception involves distributed brain regions. To investigate the network character of these regions of the human brain, we applied data-driven group spatial independent component analysis (ICA) to a functional magnetic resonance imaging (fMRI) data set acquired during a passive audio-visual (AV) experiment with common object stimuli. We labeled three group-level independent component (IC) maps as auditory (A), visual (V), and AV, based on their spatial layouts and activation time courses. The overlap between these IC maps served as definition of a distributed network of multisensory candidate regions including superior temporal, ventral occipito-temporal, posterior parietal and prefrontal regions. During an independent second fMRI experiment, we explicitly tested their involvement in AV integration. Activations in nine out of these twelve regions met the max-criterion (A < AV > V) for multisensory integration. Comparison of this approach with a general linear model-based region-of-interest definition revealed its complementary value for multisensory neuroimaging. In conclusion, we estimated functional networks of uni- and multisensory functional connectivity from one dataset and validated their functional roles in an independent dataset. These findings demonstrate the particular value of ICA for multisensory neuroimaging research and using independent datasets to test hypotheses generated from a data-driven analysis.

Item Type:Articles
Additional Information:The original publication is available at www.springerlink.com
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Muckli, Professor Lars
Authors: Naumer, M.J., van den Bosch, J., Wibral, M., Kohler, A., Singer, W., Kaiser, J., van de Ven, V., and Muckli, L.
Subjects:B Philosophy. Psychology. Religion > BF Psychology
Q Science > QM Human anatomy
R Medicine > RC Internal medicine > RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry
College/School:College of Medical Veterinary and Life Sciences > Institute of Neuroscience and Psychology
Journal Name:Experimental Brain Research
Journal Abbr.:Exp Brain Res
ISSN:0014-4819
ISSN (Online):1432-1106
Published Online:19 April 2011
Copyright Holders:Copyright © 2011 Springer
First Published:First published in Experimental Brain Research 213(2-3):309-320
Publisher Policy:Reproduced in accordance with the copyright policy of the publisher

University Staff: Request a correction | Enlighten Editors: Update this record