Clark, J.S. , Labre, F. and Thomas, L.H. (2011) Concise synthesis of the C-1–C-12 fragment of amphidinolides T1–T5. Organic and Biomolecular Chemistry, 9, pp. 4823-4830. (doi: 10.1039/c1ob05130j)
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Publisher's URL: http://dx.doi.org/10.1039/C1OB05130J
Abstract
The C-1-C-12 segment of the amphidinolides T1-T5 has been synthesised in an efficient manner. The key transformations are highly diastereoselective rearrangement of an oxonium ylide, or metal-bound ylide equivalent, produced by intramolecular reaction of a copper carbenoid with an allylic ether, and macrocyclic fragment coupling by one-pot ring-closing metathesis and hydrogenation.
| Item Type: | Articles |
|---|---|
| Status: | Published |
| Refereed: | Yes |
| Glasgow Author(s) Enlighten ID: | Clark, Professor Stephen |
| Authors: | Clark, J.S., Labre, F., and Thomas, L.H. |
| Subjects: | Q Science > QD Chemistry |
| College/School: | College of Science and Engineering > School of Chemistry |
| Journal Name: | Organic and Biomolecular Chemistry |
| ISSN: | 1477-0520 |
| ISSN (Online): | 1477-0539 |
| Published Online: | 20 April 2011 |
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