Interleukin 18 and coronary heart disease: Prospective study and systematic review

Jefferis, B.J.M.H. et al. (2011) Interleukin 18 and coronary heart disease: Prospective study and systematic review. Atherosclerosis, 217(1), pp. 227-233. (doi:10.1016/j.atherosclerosis.2011.03.015)

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Publisher's URL: http://dx.doi.org/10.1016/j.atherosclerosis.2011.03.015

Abstract

Aim: Previous studies suggest that circulating levels of interleukin-18 (IL-18) may be prospectively related to risk of coronary heart disease (CHD) in the general population. We report new data from the largest prospective study to date, which are combined with data from all published prospective studies in a meta-analysis. Methods: We measured baseline IL-18 levels in stored serum samples of subjects from a case-control study nested within a prospective study of 5661 men aged 40-59 years recruited from general practices in 18 British towns in 1978-1980 and followed-up for up to 16 years (median time to event 8.4 years) for fatal CHD and non-fatal myocardial infarction (595 cases, 1238 controls). Results: IL-18 concentrations were strongly related to cigarette smoking, triglyceride, HDL-cholesterol (inversely) and to circulating levels of several inflammatory and haemostatic markers. Men in the top third of baseline IL-18 levels had an age-adjusted odds ratio (OR) for CHD of 1.55 (95% CI 1.21, 1.98) compared with those in the lowest third; this was reduced to 1.30 (95% CI 0.99, 1.69) after additional adjustment for vascular risk factors and 1.12 (95% CI 0.84, 1.49) after further adjustment for CRP and IL-6. In meta-analyses of CVD, associations (or effect sizes) were consistent between studies; RRs were 1.63 (95% CI 1.46, 1.82) after age adjustment, 1.39 (95% CI 1.24, 1.55) after additional risk factor adjustment and 1.34 (95% CI 1.17, 1.54) after additional adjustment for inflammatory markers. Conclusions: Circulating IL-18 is prospectively and independently associated with CVD risk. (C) 2011 Elsevier Ireland Ltd. All rights reserved

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Woodward, Professor Mark and Rumley, Dr Ann and Lowe, Professor Gordon and Welsh, Dr Paul
Authors: Jefferis, B.J.M.H., Papacosta, O., Owen, C.G., Wannamethee, S.G., Humphries, S.E., Woodward, M., Lennon, L.T., Thomson, A., Welsh, P., Rumley, A., Lowe, G.D.O., and Whincup, P.H.
College/School:College of Medical Veterinary and Life Sciences > Institute of Cardiovascular and Medical Sciences
College of Medical Veterinary and Life Sciences > School of Medicine, Dentistry & Nursing
Journal Name:Atherosclerosis
Publisher:Elsevier Ireland Ltd
ISSN:0021-9150

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