Distinct functional outputs of PTEN signalling are controlled by dynamic association with β-arrestins

Lima-Fernandes, E. et al. (2011) Distinct functional outputs of PTEN signalling are controlled by dynamic association with β-arrestins. EMBO Journal, 30(13), pp. 2557-2568. (doi: 10.1038/emboj.2011.178)

Abstract

The tumour suppressor PTEN (phosphatase and tensin deleted on chromosome 10) regulates major cellular functions via lipid phosphatase-dependent and -independent mechanisms. Despite its fundamental pathophysiological importance, how PTEN's cellular activity is regulated has only been partially elucidated. We report that the scaffolding proteins beta-arrestins (beta-arrs) are important regulators of PTEN. Downstream of receptor-activated RhoA/ROCK signalling, beta-arrs activate the lipid phosphatase activity of PTEN to negatively regulate Akt and cell proliferation. In contrast, following wound-induced RhoA activation, beta-arrs inhibit the lipid phosphatase-independent anti-migratory effects of PTEN. beta-arrs can thus differentially control distinct functional outputs of PTEN important for cell proliferation and migration. The EMBO Journal (2011) 30, 2557-2568. doi:10.1038/emboj.2011.178; Published online 3 June 2011

• Item Type: Articles
• Status: Published
• Refereed: Yes
• Glasgow Author(s) Enlighten ID: Gibson, Dr Lucien and Baillie, Professor George
• Authors: Lima-Fernandes, E., Enslen, H., Camand, E., Kotelevets, L., Boularan, C., Achour, L., Benmerah, A., Gibson, L.C.D., Baillie, G.S., Pitcher, J.A., Chastre, E., Etienne-Manneville, S., Marullo, S., and Scott, M.G.H.
• College/School: College of Medical Veterinary and Life Sciences > School of Cardiovascular & Metabolic Health; College of Medical Veterinary and Life Sciences > School of Psychology & Neuroscience
• Journal Name: EMBO Journal
• ISSN: 0261-4189