Strikingly low circulating CRP concentrations in ultramarathon runners independent of markers of adiposity - How low can you go?

Tomaszewski, M. et al. (2003) Strikingly low circulating CRP concentrations in ultramarathon runners independent of markers of adiposity - How low can you go? Arteriosclerosis, Thrombosis, and Vascular Biology, 23(9), pp. 1640-1644. (doi: 10.1161/01.ATV.0000087036.75849.0B)

Full text not currently available from Enlighten.


Objective-This study was undertaken to evaluate to what extent C-reactive protein (CRP) can be reduced by exercise by examining its circulating concentrations in male ultramarathon runners and to determine if low leptin as a robust circulating marker of fat mass could account for low CRP in such men. Methods and Results-Sixty-seven male ultramarathon runners and 63 sedentary male controls of similar age and body mass index were recruited. CRP and leptin were measured by ELISA and radioimmunoassay, respectively. Median CRP concentration in lean (body mass index lt 25 kg/m(2)) marathon runners was less than half control median (0.4 [0.2 to 0.9] mg/L versus 0.9 [0.5 to 2.7] mg/L, P=0.0013) and, more strikingly, in nonlean runners was approximately 26% of control median (0.4 [0.3 to 0.8] mg/L versus 1.5 [0.9 to 2.5] mg/L, P=0.0002). Circulating leptin levels were also substantially lower in lean (45% less) and nonlean (63% less, both P=0.0001) ultramarathon runners. However, interleukin-6 levels were not different. Furthermore, leptin adjustment only minimally attenuated the case-control difference in CRP, suggesting that mechanisms other than fat mass reduction contribute to low concentrations of CRP in marathon runners. Conclusions-This study suggests that circulating CRP concentrations can be markedly suppressed, independently of total adiposity or indeed fat mass, by intense regular physical exercise.

Item Type:Articles
Glasgow Author(s) Enlighten ID:Dominiczak, Professor Anna
Authors: Tomaszewski, M., Charchar, F.J., Przybycin, M., Crawford, L., Wallace, A.M., Gosek, K., Lowe, G.D., Zukowska-Szczechowska, E., Grzeszczak, W., Sattar, N., and Dominiczak, A.F.
Subjects:R Medicine > RC Internal medicine > RC1200 Sports Medicine
Q Science > QP Physiology
College/School:College of Medical Veterinary and Life Sciences
College of Medical Veterinary and Life Sciences > School of Cardiovascular & Metabolic Health
Journal Name:Arteriosclerosis, Thrombosis, and Vascular Biology
Publisher:American Heart Association

University Staff: Request a correction | Enlighten Editors: Update this record