The Heart failure and Optimal Outcomes from Pharmacy Study (HOOPS): rationale, design, and baseline characteristics

Lowrie, R. et al. (2011) The Heart failure and Optimal Outcomes from Pharmacy Study (HOOPS): rationale, design, and baseline characteristics. European Journal of Heart Failure, 13(8), pp. 917-924. (doi:10.1093/eurjhf/hfr083)

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Publisher's URL: http://dx.doi.org/10.1093/eurjhf/hfr083

Abstract

<b>Aims</b> The effect on mortality and morbidity of pharmacist-led intervention to optimize pharmacological therapy in patients with systolic heart failure (HF) has not been tested in a large-scale, long-term, clinical trial.<p></p> <b>Methods</b> We describe the rationale and design of a UK, primary care-based, prospective cluster-randomized controlled trial of a pharmacist-led intervention in HF and report baseline characteristics of the patients randomized. Eighty-seven practices (1092 patients) were assigned to the intervention arm and 87 practices (1077 patients) to usual care. The average age of patients at baseline was 71 years, 70% were male, 86% were treated with an angiotensin-converting enzyme inhibitor or angiotensin receptor blocker and 62% with a beta-blocker. Data for the primary outcome of death from any cause or hospitalization for HF will be available up to 31 December 2010, giving a mean follow-up of 5 years. More than 750 patients would have experienced the primary outcome during this period. The first secondary outcome is death from any cause or hospitalization for a cardiovascular reason. Deaths and hospitalizations are being identified using the Scottish National Health Service electronic patient record-linkage system (hence the delay between the end of follow-up and database lock).<p></p> <b>Conclusion</b> This trial is powered to provide a robust evaluation of the effect of pharmacist-led treatment optimization in patients with systolic HF in primary care.

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Messow, Dr Martina and McConnachie, Professor Alex and Greenlaw, Miss Nicola and Morrison, Dr Deborah and Mair, Professor Frances and Lowrie, Dr Richard and McMurray, Professor John
Authors: Lowrie, R., Mair, F.S., Greenlaw, N., Forsyth, P., McConnachie, A., Richardson, J., Khan, N., Morrison, D., Messow, C.-M., Rae, B., and McMurray, J.J.V.
College/School:College of Medical Veterinary and Life Sciences > Institute of Health and Wellbeing > Robertson Centre
College of Medical Veterinary and Life Sciences > Institute of Health and Wellbeing > General Practice and Primary Care
College of Medical Veterinary and Life Sciences > Institute of Cardiovascular and Medical Sciences
College of Medical Veterinary and Life Sciences > School of Medicine, Dentistry & Nursing
Journal Name:European Journal of Heart Failure
Publisher:Oxford University Press
ISSN:1388-9842
ISSN (Online):1879-0844
Published Online:01 January 2011

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