Nodular lymphocyte predominant Hodgkin lymphoma behaves as a distinct clinical entity with good outcome: evidence from 14-year followup in the West of Scotland Cancer Network

Farrell, K., McKay, P. and Leach, M. (2011) Nodular lymphocyte predominant Hodgkin lymphoma behaves as a distinct clinical entity with good outcome: evidence from 14-year followup in the West of Scotland Cancer Network. Leukemia and Lymphoma, 52(10), pp. 1920-1928. (doi: 10.3109/10428194.2011.584993)

Abstract

Clinically and biologically, nodular lymphocyte predominant Hodgkin lymphoma (NLPHL) has much more in common with germinal-center derived B-cell non-Hodgkin lymphoma (NHL) than with classical Hodgkin lymphoma (cHL). Management of NLPHL remains controversial. In a 14-year multicenter series, 69 cases were analyzed, and the median follow-up was 53 months (range 11–165.) B-symptoms were present in only 4.3% of patients, and 81.1% of patients had stage I/II disease. Treatment was with radiotherapy (53.6%), chemotherapy (21.7%), combined modality (17.4%), and observation (7.2%). In all, 10.1% of patients relapsed and 2.9% of patients developed high-grade transformation to DLBCL. All relapses and transformations were salvageable. No patient died of their disease. The 5-year relapse-free survival was 92%, transformation-free survival 98.4%, and overall survival 100%. We conclude that NLPHL behaves as a distinct clinical entity, often presenting at an early stage without risk factors. It has an excellent outcome. It may be possible, in early-stage disease, to reduce the intensity of therapy in NLPHL, to single-modality radiotherapy, without affecting OS.

• Item Type: Articles
• Additional Information: This work has been submitted, in part, in abstract format for consideration for presentation at the 11th International Conference on Malignant Lymphoma, Lugano, June 2011. It has not been submitted elsewhere for publication.
• Status: Published
• Refereed: Yes
• Glasgow Author(s) Enlighten ID: Leach, Dr Michael and Farrell, Dr Katrina and McKay, Dr Pamela
• Authors: Farrell, K., McKay, P., and Leach, M.
• Subjects: R Medicine > R Medicine (General)
• College/School: College of Medical Veterinary and Life Sciences > School of Cancer Sciences
• Journal Name: Leukemia and Lymphoma
• Journal Abbr.: Leuk & Lymph
• Publisher: Informa Healthcare
• ISSN: 1042-8194
• ISSN (Online): 1029-2403
• Published Online: 12 June 2011
• Copyright Holders: Copyright © 2011 Informa Healthcare
• First Published: First published in Leukemia and Lymphoma 52(10):1920-1928
• Publisher Policy: Reproduced in accordance with the copyright policy of the publisher.