Sidik, N. P., Solomon, S. D., Latini, R., Maggioni, A. P., Wright, M., Gimpelewicz, C. R., Pitt, B. and McMurray, J. J. V. (2011) Effect of aliskiren in patients with heart failure according to background dose of ace inhibitor: a retrospective analysis of the aliskiren observation of heart failure treatment (ALOFT) trial. Cardiovascular Drugs and Therapy, 25(4), pp. 315-321. (doi: 10.1007/s10557-011-6319-3)
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Abstract
Aims: To compare the effect of the direct renin inhibitor aliskiren on neurohumoral activity in heart failure patients treated with low-dose and high-dose ACE inhibitor.<p></p> Methods: A retrospective analysis of the ALOFT trial. Comparison of the effects of 6 months treatment with aliskiren (versus placebo) in patients receiving n = 109) with those receiving ≥ recommended-dose (n = 81). Neurohumoral measures included B-type natriuretic peptide (BNP), NT proBNP, plasma renin activity and urinary aldosterone excretion.<p></p> Results: Patients in each ACE inhibitor-dose group were generally similar (those in the ≥ recommended ACE inhibitor-dose had higher baseline blood-pressures and LVEF and were more often female and diabetic). In the p-value 0.94. The pattern of results for other neurohumoral markers was similar.<p></p> Conclusions: Aliskiren causes neurohumoral suppression in heart failure, even in patients treated with ≥recommended-dose of ACE inhibitor.<p></p>
Item Type: | Articles |
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Status: | Published |
Refereed: | Yes |
Glasgow Author(s) Enlighten ID: | McMurray, Professor John |
Authors: | Sidik, N. P., Solomon, S. D., Latini, R., Maggioni, A. P., Wright, M., Gimpelewicz, C. R., Pitt, B., and McMurray, J. J. V. |
College/School: | College of Medical Veterinary and Life Sciences > School of Cardiovascular & Metabolic Health |
Journal Name: | Cardiovascular Drugs and Therapy |
Publisher: | Springer US |
ISSN: | 0920-3206 |
ISSN (Online): | 1573-7241 |
Published Online: | 21 July 2011 |
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