Effect of aliskiren in patients with heart failure according to background dose of ace inhibitor: a retrospective analysis of the aliskiren observation of heart failure treatment (ALOFT) trial

Sidik, N. P., Solomon, S. D., Latini, R., Maggioni, A. P., Wright, M., Gimpelewicz, C. R., Pitt, B. and McMurray, J. J. V. (2011) Effect of aliskiren in patients with heart failure according to background dose of ace inhibitor: a retrospective analysis of the aliskiren observation of heart failure treatment (ALOFT) trial. Cardiovascular Drugs and Therapy, 25(4), pp. 315-321. (doi:10.1007/s10557-011-6319-3)

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Abstract

Aims: To compare the effect of the direct renin inhibitor aliskiren on neurohumoral activity in heart failure patients treated with low-dose and high-dose ACE inhibitor.

Methods: A retrospective analysis of the ALOFT trial. Comparison of the effects of 6 months treatment with aliskiren (versus placebo) in patients receiving n = 109) with those receiving ≥ recommended-dose (n = 81). Neurohumoral measures included B-type natriuretic peptide (BNP), NT proBNP, plasma renin activity and urinary aldosterone excretion.

Results: Patients in each ACE inhibitor-dose group were generally similar (those in the ≥ recommended ACE inhibitor-dose had higher baseline blood-pressures and LVEF and were more often female and diabetic). In the p-value 0.94. The pattern of results for other neurohumoral markers was similar.

Conclusions: Aliskiren causes neurohumoral suppression in heart failure, even in patients treated with ≥recommended-dose of ACE inhibitor.

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:McMurray, Professor John
Authors: Sidik, N. P., Solomon, S. D., Latini, R., Maggioni, A. P., Wright, M., Gimpelewicz, C. R., Pitt, B., and McMurray, J. J. V.
College/School:College of Medical Veterinary and Life Sciences > Institute of Cardiovascular and Medical Sciences
Journal Name:Cardiovascular Drugs and Therapy
Publisher:Springer US
ISSN:0920-3206
ISSN (Online):1573-7241
Published Online:21 July 2011

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